HOXC10 promotes tumour metastasis by regulating the EMT-related gene Slug in ovarian cancer
metastatic symptoms. Recent studies have shown that HOX genes are crucial in tumour progression, but the underlying mechanisms remain unclear. Here, HOXC10 expression was examined in ovarian cancer tissues. The function of HOXC10 in ovarian cancer metastasis was investigated in vitroand via intraperitoneal injection in vivo. A total of 158 ovarian cancer patients with adequate records were enrolled for analysis. HOXC10 was associated with metastasis and poor prognosis in ovarian cancer. In vitro, HOXC10 overexpression promoted ovarian cancer cell migration.
Moreover, HOXC10 positively regulated Slug expression, altering the migration ability of cancer cells. Furthermore, our study showed that miR-222-3p was a suppressor of HOXC10. In vivo, a decrease in hepatic metastasis was seen in xenograft mice harbouring tumours with stable HOXC10 overexpression after miR-222-3p agomir (an overexpression reagent) injection. This study provides the first evidence that HOXC10 promotes ovarian cancer metastasis by regulating the transcription of the EMT-related gene Slug. Moreover, we found that HOXC10 is regulated by miR-222-3p. These data highlight the crucial role of HOXC10 in enhancing ovarian cancer metastasis and may provide a therapeutic target for ovarian cancer.
Canine Parvovirus Antigen |
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NAT41594-100 | The Native Antigen Company | 0.1 | EUR 395.28 |
Description: Canine Parvovirus, produced in CRFK cells. |
Sm Antigen |
|||
DAG-T1227 | Creative Diagnostics | 200 ug | EUR 1286.25 |
Sm Antigen |
|||
GWB-D554DD | GenWay Biotech | 0.2 mg | Ask for price |
Sm Antigen |
|||
GWB-4C4962 | GenWay Biotech | 0.2 mg | Ask for price |
Sm Antigen |
|||
MBS318131-02mg | MyBiosource | 0.2mg | EUR 1320 |
Sm Antigen |
|||
MBS318131-5x02mg | MyBiosource | 5x0.2mg | EUR 5685 |
Canine Coronavirus Antigen |
|||
NAT41590-100 | The Native Antigen Company | 0.1 | EUR 395.28 |
Description: Canine Coronavirus produced in A-72 cells. |
Feline Calicivirus Antigen |
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NAT41595-100 | The Native Antigen Company | 0.1 | EUR 395.28 |
Description: Feline Calicivirus produced in FC 3TG cells. |
Helicobacter Pylori Antigen |
|||
NAT41603-100 | The Native Antigen Company | 0.1 | EUR 395.28 |
Description: Bacteria are cultured on solid medium, harvested, washed and solubilised. The antigen is partially purified by detergent extraction and centrifugation. |
Helicobacter Pylori Antigen |
|||
NAT41603-500 | The Native Antigen Company | 0.5 | EUR 1187.13 |
Description: Bacteria are cultured on solid medium, harvested, washed and solubilised. The antigen is partially purified by detergent extraction and centrifugation. |
Campylobacter Jejuni Antigen |
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NAT41600-100 | The Native Antigen Company | 0.1 | EUR 395.28 |
Description: Campylobacter jejuni is cultured on solid medium. This antigen is a partially purified detergent extract of the membrane fraction. The main component is an outer membrane protein, approximately 45 kDa in SDS-PAGE. |
Campylobacter Jejuni Antigen |
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NAT41600-500 | The Native Antigen Company | 0.5 | EUR 1187.13 |
Description: Campylobacter jejuni is cultured on solid medium. This antigen is a partially purified detergent extract of the membrane fraction. The main component is an outer membrane protein, approximately 45 kDa in SDS-PAGE. |
Chlamydia Trachomatis Antigen |
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CT022-1000 | The Native Antigen Company | 1.0 | EUR 382.41 |
Description: Chlamydia trachomatis antigens from clarified cell lysate. |
Mycoplasma Pneumoniae Antigen |
|||
MP901-1000 | The Native Antigen Company | 1.0 | EUR 1019.75 |
Description: Mycoplasma pneumoniae whole organisms that have been purified and detergent treated to enrich antigenic proteins and decrease background. |
Mycoplasma Pneumoniae Antigen |
|||
MP901-200 | The Native Antigen Company | 0.2 | EUR 272.96 |
Description: Mycoplasma pneumoniae whole organisms that have been purified and detergent treated to enrich antigenic proteins and decrease background. |
Neisseria Gonorrhoeae Antigen |
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NG01-1000 | The Native Antigen Company | 1.0 | EUR 382.41 |
Description: Homogenised lysate of pure bacteria. |
Echovirus Antigen, Recombinant |
|||
REC31776-100 | The Native Antigen Company | 0.1 | EUR 279.4 |
Description: Proprietary recombinant antigen expressed in E. coli and purified by chromatography. Individually pooled antigens shown to react with QC serum panel (multiple negative, borderline and positive sera) within defined reactivity range in Coxsackie-/Echovirus |
Echovirus Antigen, Recombinant |
|||
REC31776-500 | The Native Antigen Company | 0.5 | EUR 1053.23 |
Description: Proprietary recombinant antigen expressed in E. coli and purified by chromatography. Individually pooled antigens shown to react with QC serum panel (multiple negative, borderline and positive sera) within defined reactivity range in Coxsackie-/Echovirus |
Trichomonas Vaginalis Antigen |
|||
TV01-1000 | The Native Antigen Company | 1.0 | EUR 424.9 |
Description: Washed & lysed suspension of whole protozoa |
Echinococcus Granulosus Antigen |
|||
NAT41602-100 | The Native Antigen Company | 0.1 | EUR 395.28 |
Description: Echinococcus granulosus material is derived from bovine hydatid cyst as sterile filtered cyst fluid. |
Echinococcus Granulosus Antigen |
|||
NAT41602-500 | The Native Antigen Company | 0.5 | EUR 1187.13 |
Description: Echinococcus granulosus material is derived from bovine hydatid cyst as sterile filtered cyst fluid. |
Enterovirus Antigen, Recombinant |
|||
REC31772-100 | The Native Antigen Company | 0.1 | EUR 279.4 |
Description: Proprietary recombinant antigen expressed in E. coli and purified by chromatography. Individually pooled antigens shown to react with QC serum panel (multiple negative, borderline and positive sera) within defined reactivity range in Coxsackie-/Echovirus IgA, IgG and IgM ELISA. |
Enterovirus Antigen, Recombinant |
|||
REC31772-500 | The Native Antigen Company | 0.5 | EUR 1053.23 |
Description: Proprietary recombinant antigen expressed in E. coli and purified by chromatography. Individually pooled antigens shown to react with QC serum panel (multiple negative, borderline and positive sera) within defined reactivity range in Coxsackie-/Echovirus IgA, IgG and IgM ELISA. |
Cytomegalovirus Purified Antigen |
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CMV-HP-100 | The Native Antigen Company | 0.1 | EUR 321.89 |
Description: A concentrated source of human Cytomegalovirus particles purified by sucrose gradient ultracentrifugation. |
Cytomegalovirus Purified Antigen |
|||
CMV-HP-1000 | The Native Antigen Company | 1.0 | EUR 2115.47 |
Description: A concentrated source of human Cytomegalovirus particles purified by sucrose gradient ultracentrifugation. |
Cytomegalovirus Purified Antigen |
|||
CMV-HP-500 | The Native Antigen Company | 0.5 | EUR 1291.43 |
Description: A concentrated source of human Cytomegalovirus particles purified by sucrose gradient ultracentrifugation. |
Astrovirus Antigen (Type 1) |
|||
AS02-1000 | The Native Antigen Company | 1.0 | EUR 1669.97 |
Description: A concentrated source of Astrovirus particles and Astrovirus proteins from a lysate of host cells. |
Astrovirus Antigen (Type 1) |
|||
AS02-200 | The Native Antigen Company | 0.2 | EUR 446.78 |
Description: A concentrated source of Astrovirus particles and Astrovirus proteins from a lysate of host cells. |
Yersinia pestis V antigen |
|||
REC32028-100 | The Native Antigen Company | 0.1 | EUR 326.34 |
Description: Yersinia pestis V antigen (LcrV antigen, capsule protein fraction 1, type III secretion system needle tip protein). The protein is produced as an N-terminal GST fusion, with GST being cleaved by thrombin and is not present in the final product. |
Yersinia pestis V antigen |
|||
REC32028-500 | The Native Antigen Company | 0.5 | EUR 1386.95 |
Description: Yersinia pestis V antigen (LcrV antigen, capsule protein fraction 1, type III secretion system needle tip protein). The protein is produced as an N-terminal GST fusion, with GST being cleaved by thrombin and is not present in the final product. |
Canine Herpes Virus Antigen |
|||
NAT41592-100 | The Native Antigen Company | 0.1 | EUR 395.28 |
Description: Canine Herpes virus, produced in MDCK cells. |
Canine Adenovirus 1 Antigen |
|||
NAT41587-100 | The Native Antigen Company | 0.1 | EUR 395.28 |
Description: Canine Adenovirus Type 1, produced in A-72 cells. |
Canine Adenovirus 2 Antigen |
|||
NAT41588-100 | The Native Antigen Company | 0.1 | EUR 395.28 |
Description: Canine Adenovirus Type 2, produced in A-72 cells. |
Toxoplasma gondii IgM antigen |
|||
TG-IgM-100 | The Native Antigen Company | 0.1mg | EUR 139.86 |
Description: A highly purified source of Toxoplasma gondii membrane antigens, optimised for IgM detection. |
Toxoplasma gondii IgM antigen |
|||
TG-IgM-1000 | The Native Antigen Company | 1.0mg | EUR 1189.51 |
Description: A highly purified source of Toxoplasma gondii membrane antigens, optimised for IgM detection. |
Canine Distemper Virus Antigen |
|||
NAT41591-100 | The Native Antigen Company | 0.1 | EUR 395.28 |
Description: Canine Distemper virus, produced in SL-29 cells. |
Canine Parainfluenza Virus Antigen |
|||
NAT41593-100 | The Native Antigen Company | 0.1 | EUR 395.28 |
Description: Canine Parainfluenza virus antigen, produced in MDCK cells. |
Feline Panleukopenia Virus Antigen |
|||
NAT41597-100 | The Native Antigen Company | 0.1 | EUR 395.28 |
Description: Feline Panleukopenia Virus (FPLV; feline parvovirus) antigen, produced in CRFK cells. |
Norovirus GII.4 VP1 Antigen |
|||
REC31620-100 | The Native Antigen Company | 0.1 | EUR 305.15 |
Description: Recombinant Norovirus GII.4 VP1 antigen produced in 293 human cells. |
Norovirus GII.4 VP1 Antigen |
|||
REC31620-1000 | The Native Antigen Company | 1.0 | EUR 1847.65 |
Description: Recombinant Norovirus GII.4 VP1 antigen produced in 293 human cells. |
Norovirus GII.4 VP1 Antigen |
|||
REC31620-500 | The Native Antigen Company | 0.5 | EUR 1076.4 |
Description: Recombinant Norovirus GII.4 VP1 antigen produced in 293 human cells. |
Cytomegalovirus Cell Lysate Antigen |
|||
CMV-CL-100 | The Native Antigen Company | 0.1 | EUR 225.32 |
Description: A clarified cell lysate containing a mix of CMV antigens from all stages of the replication life cycle. |
Cytomegalovirus Cell Lysate Antigen |
|||
CMV-CL-1000 | The Native Antigen Company | 1.0 | EUR 1435.63 |
Description: A clarified cell lysate containing a mix of CMV antigens from all stages of the replication life cycle. |
Feline Viral Rhinotracheitis Antigen |
|||
NAT41598-100 | The Native Antigen Company | 0.1 | EUR 395.28 |
Description: Feline Viral Rhinotracheitis (FVR; feline herpes virus, FHV-1) antigen, produced in CRFK cells. |
Herpes Simplex Virus 1 Antigen |
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HS105-1000 | The Native Antigen Company | 1.0 | EUR 1189.71 |
Description: HSV-1 particles from a cell lysate are purified by sucrose gradient ultracentrifugation. |
Herpes Simplex Virus 1 Antigen |
|||
HS105-200 | The Native Antigen Company | 0.2 | EUR 297.43 |
Description: HSV-1 particles from a cell lysate are purified by sucrose gradient ultracentrifugation. |
Herpes Simplex Virus 2 Antigen |
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HS205-1000 | The Native Antigen Company | 1.0 | EUR 1189.71 |
Description: HSV-2 particles from a cell lysate are purified by sucrose gradient ultracentrifugation. |
Herpes Simplex Virus 2 Antigen |
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HS205-200 | The Native Antigen Company | 0.2 | EUR 297.43 |
Description: HSV-2 particles from a cell lysate are purified by sucrose gradient ultracentrifugation. |
Ross River Virus Recombinant Antigen |
|||
REC31969-100 | The Native Antigen Company | 0.1 | EUR 764.81 |
Description: Recombinant Ross River virus antigen expressed in HEK293 cells as virus-like particles and purified by sucrose density gradients and precipitation. Virus-like particles were then solubilized in PBS containing 0.2% SDS to prevent aggregation of particles. The preparation is not particulate. Antigens in the preparation include Envelope proteins 1 and 2 and Nucleoprotein. |
Ross River Virus Recombinant Antigen |
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REC31969-500 | The Native Antigen Company | 0.5 | EUR 2871.26 |
Description: Recombinant Ross River virus antigen expressed in HEK293 cells as virus-like particles and purified by sucrose density gradients and precipitation. Virus-like particles were then solubilized in PBS containing 0.2% SDS to prevent aggregation of particles. The preparation is not particulate. Antigens in the preparation include Envelope proteins 1 and 2 and Nucleoprotein. |
Canine Adenovirus 1 and 2 Antigen |
|||
NAT41589-100 | The Native Antigen Company | 0.1 | EUR 395.28 |
Description: A mixture of Canine Adenovirus Type 1 and Type 2, produced in A-72 cells. |
Hepatitis B Virus E Antigen (HBeAg) |
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REC31677-100 | The Native Antigen Company | 0.1 | EUR 460.95 |
Description: Recombinant Hepititis B Virus E Protein (HBeAg). |
Hepatitis B Virus E Antigen (HBeAg) |
|||
REC31677-500 | The Native Antigen Company | 0.5 | EUR 1382.84 |
Description: Recombinant Hepititis B Virus E Protein (HBeAg). |
Hepatitis B Virus Core Antigen (HBcAg) |
|||
REC31689-100 | The Native Antigen Company | 0.1 | EUR 460.95 |
Description: Recombinant Hepititis B Virus Core Protein (HBcAg). |
Hepatitis B Virus Core Antigen (HBcAg) |
|||
REC31689-500 | The Native Antigen Company | 0.5 | EUR 1382.84 |
Description: Recombinant Hepititis B Virus Core Protein (HBcAg). |
Hepatitis C Virus Core Antigen (HCcAg) |
|||
REC31693-100 | The Native Antigen Company | 0.1 | EUR 489.27 |
Description: Recombinant Hepatitis C Virus core protein is produced in E. coli and fused with a His-tag. |
Hepatitis C Virus Core Antigen (HCcAg) |
|||
REC31693-500 | The Native Antigen Company | 0.5 | EUR 1469.11 |
Description: Recombinant Hepatitis C Virus core protein is produced in E. coli and fused with a His-tag. |
Feline Infectious Peritonitis Virus Antigen |
|||
NAT41596-100 | The Native Antigen Company | 0.1 | EUR 395.28 |
Description: Feline Infectious Peritonitis virus (FIPV; feline coronavirus) antigen, produced in CRFK cells. |
Herpes Simplex Virus 1 Lysate Antigen |
|||
HS104-1000 | The Native Antigen Company | 1.0 | EUR 272.96 |
Description: A high concentration of HSV-1 particles and proteins from a clarified cell lysate. |
Herpes Simplex Virus 2 Lysate Antigen |
|||
HS204-1000 | The Native Antigen Company | 1.0 | EUR 272.96 |
Description: A high concentration of HSV-2 particles and proteins from a clarified cell lysate. |
Toxoplasma gondii IgG antigen, RH strain |
|||
TG-IgG-1000 | The Native Antigen Company | 1.0 mg | EUR 338 |
Description: A concentrated source of Toxoplasma gondii tachyzoite antigens, optimised for IgG detection, diluted to 0.5 mg/ml. |
Toxoplasma gondii IgG antigen, RH strain |
|||
TG-IgG-200 | The Native Antigen Company | 0.2 mg | EUR 174.83 |
Description: A concentrated source of Toxoplasma gondii tachyzoite antigens, optimised for IgG detection, diluted to 0.5 mg/ml. |
Toxoplasma gondii IgG antigen, RH strain |
|||
TG-IgG-5000 | The Native Antigen Company | 5.0 mg | EUR 1436.48 |
Description: A concentrated source of Toxoplasma gondii tachyzoite antigens, optimised for IgG detection, diluted to 0.5 mg/ml. |
Legionella pneumophila antigen (native extract) |
|||
NAT41580-100 | The Native Antigen Company | 0.1 | EUR 395.28 |
Description: Inactivated Legionella pneumophila antigen from culture. |
Streptococcus Pneumoniae Antigen, Native Extract |
|||
NAT41604-100 | The Native Antigen Company | 0.1 | EUR 395.28 |
Description: Inactivated Streptococcus pneumoniae antigen from culture. |
Leptospira Biflexa Antigen (Strain Patoc 1) |
|||
NAT41582-100 | The Native Antigen Company | 0.1 | EUR 395.28 |
Description: Inactivated Leptospira biflexa antigen (Strain Patoc 1) from broth culture. |
Leptospira Biflexa Antigen (Strain Patoc 1) |
|||
NAT41582-500 | The Native Antigen Company | 0.5 | EUR 1187.13 |
Description: Inactivated Leptospira biflexa antigen (Strain Patoc 1) from broth culture. |
RNP/Sm Antigen |
|||
DAG-T1223 | Creative Diagnostics | 200 ug | EUR 829.5 |
Sm/RNP Antigen |
|||
GWB-CA4A65 | GenWay Biotech | 0.2 mg | Ask for price |
Sm/RNP Antigen |
|||
GWB-CDBE95 | GenWay Biotech | 1000 Units | Ask for price |
Sm/RNP Antigen |
|||
MBS318016-1000Units | MyBiosource | 1000Units | EUR 725 |
Sm/RNP Antigen |
|||
MBS318016-5x1000Units | MyBiosource | 5x1000Units | EUR 3010 |
Sm/RNP Antigen |
|||
MBS318132-02mg | MyBiosource | 0.2mg | EUR 555 |
Sm/RNP Antigen |
|||
MBS318132-5x02mg | MyBiosource | 5x0.2mg | EUR 2260 |
Sm/RNP Antigen |
|||
MBS634961-02mg | MyBiosource | 0.2mg | EUR 700 |
Sm/RNP Antigen |
|||
MBS634961-5x02mg | MyBiosource | 5x0.2mg | EUR 3010 |
Sm/RNP Antigen |
|||
MBS651601-1000Units | MyBiosource | 1000Units | EUR 925 |
Sm/RNP Antigen |
|||
MBS651601-5x1000Units | MyBiosource | 5x1000Units | EUR 3935 |
Sm/nRNP Antigen |
|||
MBS634639-5mg | MyBiosource | 5mg | EUR 400 |
Sm/nRNP Antigen |
|||
MBS634639-5x5mg | MyBiosource | 5x5mg | EUR 1645 |
Sm (Smith) Antigen |
|||
GWB-C86F77 | GenWay Biotech | 1000 Units | Ask for price |
Sm (Smith) Antigen |
|||
MBS318015-1000Units | MyBiosource | 1000Units | EUR 1390 |
Sm (Smith) Antigen |
|||
MBS318015-5x1000Units | MyBiosource | 5x1000Units | EUR 6020 |
Sm (Smith) Antigen |
|||
MBS651602-02mg | MyBiosource | 0.2mg | EUR 1585 |
Sm (Smith) Antigen |
|||
MBS651602-5x02mg | MyBiosource | 5x0.2mg | EUR 6905 |
Sm (Smith) Antigen |
|||
MBS651603-1000Units | MyBiosource | 1000Units | EUR 1730 |
Sm (Smith) Antigen |
|||
MBS651603-5x1000Units | MyBiosource | 5x1000Units | EUR 7555 |
Sm (Smith) Antigen |
|||
MBS6508269-05mL | MyBiosource | 0.5mL | EUR 820 |
Sm (Smith) Antigen |
|||
MBS6508269-5x05mL | MyBiosource | 5x0.5mL | EUR 3530 |
Sm Antigen Antibody |
|||
GWB-F7DFEA | GenWay Biotech | 2 ml | Ask for price |
Mouse Anti-Hepatitis B Surface Antigen Antibody (1834) |
|||
MAB12230-100 | The Native Antigen Company | 0.1 | EUR 278.11 |
Description: Mouse monoclonal antibody specific for Hepatitis B virus surface antigen (1834). |
Mouse Anti-Hepatitis B Surface Antigen Antibody (1837) |
|||
MAB12231-100 | The Native Antigen Company | 0.1 | EUR 278.11 |
Description: Mouse monoclonal antibody specific for Hepatitis B virus surface antigen (1837) |
Mouse Anti-Hepatitis B Surface Antigen Antibody (1838) |
|||
MAB12232-100 | The Native Antigen Company | 0.1 | EUR 278.11 |
Description: Mouse monoclonal antibody specific for Hepatitis B virus surface antigen (1838) |
Mouse Anti-Hepatitis B Virus E Antigen Antibody (1892) |
|||
MAB12226-100 | The Native Antigen Company | 0.1 | EUR 198.28 |
Description: Mouse monoclonal antibody specific for Hepatitis B virus e antigen (1892) |
Mouse Anti-Hepatitis B Virus E Antigen Antibody (1893) |
|||
MAB12227-100 | The Native Antigen Company | 0.1 | EUR 278.11 |
Description: Mouse monoclonal antibody specific for Hepatitis B virus e antigen (1893) |
Mouse Anti-Hepatitis B Virus E Antigen Antibody (1894) |
|||
MAB12228-100 | The Native Antigen Company | 0.1 | EUR 278.11 |
Description: Mouse monoclonal antibody specific for Hepatitis B virus e antigen (1894) |
Mouse Anti-Hepatitis B Virus E Antigen Antibody (M132) |
|||
MAB12298-100 | The Native Antigen Company | 0.1 | EUR 279.4 |
Description: Mouse monoclonal antibody specific for Hepatitis B virus e antigen (M132) |
Mouse Anti-Hepatitis B Virus E Antigen Antibody (M132) |
|||
MAB12298-500 | The Native Antigen Company | 0.5 | EUR 701.72 |
Description: Mouse monoclonal antibody specific for Hepatitis B virus e antigen (M132) |
Mouse Anti-Hepatitis B Virus E Antigen Antibody (M133) |
|||
MAB12299-100 | The Native Antigen Company | 0.1 | EUR 279.4 |
Description: Mouse monoclonal antibody specific for Hepatitis B virus e antigen (M133) |
Mouse Anti-Hepatitis B Virus E Antigen Antibody (M133) |
|||
MAB12299-500 | The Native Antigen Company | 0.5 | EUR 701.72 |
Description: Mouse monoclonal antibody specific for Hepatitis B virus e antigen (M133) |
Human anti Sm Antigen |
|||
MBS315463-2mL | MyBiosource | 2mL | EUR 360 |
Human anti Sm Antigen |
|||
MBS315463-5x2mL | MyBiosource | 5x2mL | EUR 1445 |
Sm (Smith) Antigen Antibody |
|||
abx022698-2ml | Abbexa | 2 ml | EUR 543.6 |
Smith Antigen (Sm) Antibody |
|||
abx022698-400l | Abbexa | 400 µl | Ask for price |
Smith Antigen (Sm) Antibody |
|||
abx022698-80l | Abbexa | 80 µl | EUR 575 |
Yersinia pestis chain B F1 capsule antigen, C-terminal His-tag |
|||
REC32027-100 | The Native Antigen Company | 0.1 | EUR 326.34 |
Description: Yersinia pestis chain B F1 capsule antigen (Antig_Caf1) |
Yersinia pestis chain B F1 capsule antigen, C-terminal His-tag |
|||
REC32027-500 | The Native Antigen Company | 0.5 | EUR 1386.95 |
Description: Yersinia pestis chain B F1 capsule antigen (Antig_Caf1) |
RNP 68K Antigen (Sm-free) |
|||
DAG-T1221 | Creative Diagnostics | 200 ug | EUR 1302 |
Sm (Smith) Antigen, Rabbit Thymus |
|||
MBS651594-1mg | MyBiosource | 1mg | EUR 320 |
Sm (Smith) Antigen, Rabbit Thymus |
|||
MBS651594-5mg | MyBiosource | 5mg | EUR 475 |
Sm (Smith) Antigen, Rabbit Thymus |
|||
MBS651594-5x5mg | MyBiosource | 5x5mg | EUR 1975 |
OPMA04152-1000IU - Sm (Smith) Antigen |
|||
OPMA04152-1000IU | Aviva Systems Biology | 1000UNITS | EUR 1499 |
OPMA04227-200UG - Sm Antigen Protein |
|||
OPMA04227-200UG | Aviva Systems Biology | 0.2MG | EUR 1399 |
Sm (Smith) Antigen (BSA & Azide Free) |
|||
MBS6268168-01mL | MyBiosource | 0.1mL | EUR 1155 |
Sm (Smith) Antigen (BSA & Azide Free) |
|||
MBS6268168-5x01mL | MyBiosource | 5x0.1mL | EUR 5050 |
Sm (Smith) Antigen (BSA & Azide Free) |
|||
MBS6005941-01mL | MyBiosource | 0.1(mL | EUR 875 |
Sm (Smith) Antigen (BSA & Azide Free) |
|||
MBS6005941-5x01mL | MyBiosource | 5x0.1mL | EUR 3785 |
OPMA04228-200UG - Sm/RNP Antigen Protein |
|||
OPMA04228-200UG | Aviva Systems Biology | 0.2MG | EUR 529 |
OPMA04153-1000IU - Sm/RNP Antigen Protein |
|||
OPMA04153-1000IU | Aviva Systems Biology | 1000UNITS | EUR 749 |
Sm (Smith) Antigen (BSA & Azide Free) (PE) |
|||
MBS6267048-01mL | MyBiosource | 0.1mL | EUR 1155 |
Sm (Smith) Antigen (BSA & Azide Free) (PE) |
|||
MBS6267048-5x01mL | MyBiosource | 5x0.1mL | EUR 5050 |
Sm (Smith) Antigen (BSA & Azide Free) (AP) |
|||
MBS6265926-01mL | MyBiosource | 0.1mL | EUR 1155 |
Sm (Smith) Antigen (BSA & Azide Free) (AP) |
|||
MBS6265926-5x01mL | MyBiosource | 5x0.1mL | EUR 5050 |
Sm (Smith) Antigen (BSA & Azide Free) (HRP) |
|||
MBS6266822-01mL | MyBiosource | 0.1mL | EUR 1155 |
Sm (Smith) Antigen (BSA & Azide Free) (HRP) |
|||
MBS6266822-5x01mL | MyBiosource | 5x0.1mL | EUR 5050 |
Comparison between Single- and Group-housed Pregnant Sows for Direct and Indirect Physiological, Reproductive, Welfare Indicators and Gene Expression Profiling
Single- and group-housed pregnant sows were assessed during 8 weeks (4th and 8th to 14th) with regard to physiological, reproductive, welfare indicators and gene expression profiling. Compared to single-housed sows, group-housed sows had decreased non-return to estrus at 56 days after artificial insemination (AI) (83% vs 92%) and farrowing rate (78% vs 88%), respectively. Furthermore, group-housed sows showed a higher degree (p < 0.01) of advantageous physiological indicators, such as albumin (odds ratio [OR] = 4.4), alkaline phosphatase (OR = 1.5), bactericidal (OR = 3.2) and complement (OR = 24.3), and disadvantageous for alanine amino transferase (OR = 0.5), bilirubin (OR = 0.4), lysozyme (OR = 0.3) and C-reactive protein compared to single-housed.
Eighty-seven genes related to immune response were underexpressed (log fold change ≤ 1.5; p < 0.05) during the 8th to 14th weeks in the group compared to single-housed sows, which in turn showed an immunomodulatory reduction on the expression of 43 genes during the 11th to 14th compared to the 4th week. Overall, the results were interpreted as indicative of greater comfort state of the group compared to single-housed sows.
Syndecan-1 and KRAS Gene Expression Signature Associates With Patient Survival in Pancreatic Cancer
- Objectives: The purpose of this study was to investigate the association of syndecan-1 (SDC1) and KRAS molecular characteristics with patient survival in pancreatic cancer.
- Methods: Both SDC1 mRNA and methylation and KRAS mRNA and somatic mutations, as well as clinical data were retrieved from a The Cancer Genome Alta pancreatic cancer data set for survival analyses. Kyoto Encyclopedia of Gene and Genomes pathway analysis for coexpressed genes for either SDC1 or KRAS was performed, respectively.
- Results: A significantly negative correlation existed between SDC1 mRNA and DNA methylation. Patients with KRAS somatic mutations had a significantly higher SDC1 mRNA but lower methylation than those without the mutations. Compared with patients with KRASSDC1 signature, those with a high level of KRAS and SDC1 alone or both had a significantly elevated mortality. The adjusted hazard ratios (95% confidence interval) were 2.30 (1.16-4.54, P = 0.017) for KRASSDC1, 2.85 (1.48-5.49, P = 0.002) for KRASSDC1, and 2.48 (1.31-4.70, P = 0.005) for KRASSDC1, respectively. Several Kyoto Encyclopedia of Gene and Genomes pathways were shared, whereas there were distinct pathways between KRAS and SDC1 coexpressed genes.
- Conclusions: SDC1 interplays with KRAS, and targeting both KRAS and SDC1 in combination may be more beneficial to pancreatic cancer patients.
Short communication: Genome-wide identification of new reference genes for reverse-transcription quantitative PCR in Streptococcus thermophilus based on RNA-sequencing analysis
Streptococcus thermophilus, one of the most important industrial lactic acid bacteria, is widely used for the production of fermented dairy products such as yogurt and cheese. The accuracy of gene expression-based analyses (e.g., reverse-transcription quantitative real-time PCR) relies heavily on the selection of reliable reference genes (RG), which provides the basis for correctly interpreting expression data. However, many traditional RG are not stably expressed in different systems. Here we used RNA-sequencing to systematically investigate gene expression variation at the genome scale and identify more stable RG in S. thermophilus.
In total, 21 putative candidate RG were identified with variation coefficient values <10.0 based on the expression of all 1,911 genes under 4 different experimental conditions. We selected and validated 12 RG chosen from transcriptomes by using reverse-transcription quantitative real-time PCR, and ranked their expression stability by statistical algorithms geNorm and NormFinder. Compared with traditional RG 16S rRNA, genes encoding glycine-tRNA ligase subunit β GlyS and fatty acid-binding protein DegV were more stable under all 4 treatments, which have never been used as RG in S. thermophilus. Our finding provides the foundation for more precise analysis of gene expression in S. thermophilus and other lactic acid bacteria species.
PLDN antibody |
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70R-35798 | Fitzgerald | 100 ug | EUR 420 |
Description: Rabbit polyclonal PLDN antibody |
PLDN antibody |
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10R-7094 | Fitzgerald | 100 ul | EUR 709 |
Description: Mouse monoclonal PLDN antibody |
PLDN Antibody |
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DF12041 | Affbiotech | 200ul | EUR 420 |
PLDN Antibody |
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DF12041-100ul | Affinity Biosciences | 100ul | EUR 168 |
Description: WB,IHC |
PLDN Antibody |
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DF12041-200ul | Affinity Biosciences | 200ul | EUR 210 |
Description: WB,IHC |
Pldn Antibody |
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CSB-PA250197XA01DLU-02mg | Cusabio | 0.2mg | Ask for price |
Description: Recombinant Drosophila melanogaster (Fruit fly) Pldn protein |
Pldn Antibody |
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CSB-PA250197XA01DLU-10mg | Cusabio | 10mg | Ask for price |
Description: Recombinant Drosophila melanogaster (Fruit fly) Pldn protein |
PLDN Antibody |
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E306292 | EnoGene | 100ug/200ul | EUR 275 |
Description: Available in various conjugation types. |
PLDN Antibody |
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E94620a | EnoGene | 100μg | EUR 255 |
Description: Available in various conjugation types. |
PLDN Antibody |
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GWB-MT596B | GenWay Biotech | 50ug | Ask for price |
PLDN Antibody |
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GWB-MT597C | GenWay Biotech | 50ug | Ask for price |
PLDN Antibody |
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MBS5313341-01mg | MyBiosource | 0.1mg | EUR 635 |
PLDN Antibody |
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MBS5313341-5x01mg | MyBiosource | 5x0.1mg | EUR 2705 |
Pldn Antibody |
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MBS7146779-INQUIRE | MyBiosource | INQUIRE | Ask for price |
PLDN Antibody |
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MBS8504430-01mg | MyBiosource | 0.1mg | EUR 345 |
PLDN Antibody |
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MBS8504430-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
PLDN Antibody |
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MBS8504430-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
PLDN Antibody |
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MBS8504430-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
PLDN Antibody |
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MBS8504430-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
PLDN Antibody |
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MBS8500526-01mL | MyBiosource | 0.1mL | EUR 325 |
PLDN Antibody |
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MBS8500526-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
PLDN Antibody |
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MBS8500526-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
PLDN Antibody |
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MBS8500526-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
PLDN Antibody |
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MBS8500526-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
PLDN antibody |
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MBS833260-01mL | MyBiosource | 0.1mL | EUR 1095 |
PLDN antibody |
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MBS833260-5x01mL | MyBiosource | 5x0.1mL | EUR 4770 |
PLDN Antibody |
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MBS9402924-01mL | MyBiosource | 0.1mL | EUR 420 |
PLDN Antibody |
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MBS9402924-5x01mL | MyBiosource | 5x0.1mL | EUR 1740 |
PLDN Antibody |
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MBS8584827-01mg | MyBiosource | 0.1mg | EUR 325 |
PLDN Antibody |
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MBS8584827-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
PLDN Antibody |
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MBS8584827-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
PLDN Antibody |
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MBS8584827-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
PLDN Antibody |
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MBS8584827-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
PLDN Antibody |
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MBS9603269-01mL | MyBiosource | 0.1mL | EUR 260 |
PLDN Antibody |
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MBS9603269-02mL | MyBiosource | 0.2mL | EUR 305 |
PLDN Antibody |
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MBS9603269-5x02mL | MyBiosource | 5x0.2mL | EUR 1220 |
anti- PLDN antibody |
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FNab06531 | FN Test | 100µg | EUR 606.3 |
Description: Antibody raised against PLDN |
PLDN antibody - middle region |
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MBS3211925-01mL | MyBiosource | 0.1mL | EUR 455 |
PLDN antibody - middle region |
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MBS3211925-5x01mL | MyBiosource | 5x0.1mL | EUR 1995 |
Pallidin Homolog (PLDN) Antibody |
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abx114318-100l | Abbexa | 100 µl | EUR 612.5 |
Pallidin Homolog (PLDN) Antibody |
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20-abx114318 | Abbexa |
|
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OAEB01601-100UG - PLDN Antibody |
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OAEB01601-100UG | Aviva Systems Biology | 100ug | EUR 349 |
PLDN antibody - N-terminal region |
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MBS3211924-01mL | MyBiosource | 0.1mL | EUR 455 |
PLDN antibody - N-terminal region |
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MBS3211924-5x01mL | MyBiosource | 5x0.1mL | EUR 1995 |
Polyclonal PLDN antibody - middle region |
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AMM07239G | Leading Biology | 0.05mg | EUR 633.6 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PLDN - middle region. This antibody is tested and proven to work in the following applications: |
ARP54890_P050-25UL - PLDN Antibody - middle region |
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ARP54890_P050-25UL | Aviva Systems Biology | 25ul | EUR 99 |
ARP54890_P050 - PLDN antibody - middle region (ARP54890_P050) |
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ARP54890_P050 | Aviva Systems Biology | 100ul | EUR 389 |
ARP54889_P050-25UL - PLDN Antibody - N-terminal region |
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ARP54889_P050-25UL | Aviva Systems Biology | 25ul | EUR 99 |
ARP54889_P050 - PLDN antibody - N-terminal region (ARP54889_P050) |
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ARP54889_P050 | Aviva Systems Biology | 100ul | EUR 389 |
PLDN |
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CSB-CL890745HU | Cusabio | 10 μg plasmid + 200μl Glycerol | Ask for price |
PLDN |
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MBS129253-002mL | MyBiosource | 0.02mL | EUR 200 |
PLDN |
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MBS129253-005mL | MyBiosource | 0.05mL | EUR 255 |
PLDN |
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MBS129253-01mL | MyBiosource | 0.1mL | EUR 345 |
PLDN |
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MBS129253-02mL | MyBiosource | 0.2mL | EUR 545 |
PLDN |
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MBS129253-5x02mL | MyBiosource | 5x0.2mL | EUR 2265 |
PLDN |
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pro-1068 | ProSpec Tany | 2µg | EUR 60 |
Description: Recombinant Human Pallidin Homolog |
Biogenesis of Lysosomal Organelles Complex 1 Subunit 6 (PLDN) Antibody |
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abx036189-100g | Abbexa | 100 µg | EUR 337.5 |
Biogenesis of Lysosomal Organelles Complex 1 Subunit 6 (PLDN) Antibody |
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abx036189-100ug | Abbexa | 100 ug | EUR 469.2 |
Biogenesis of Lysosomal Organelles Complex 1 Subunit 6 (PLDN) Antibody |
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abx236531-100g | Abbexa | 100 µg | EUR 350 |
Biogenesis of Lysosomal Organelles Complex 1 Subunit 6 (PLDN) Antibody |
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abx236531-100ug | Abbexa | 100 ug | EUR 577.2 |
PLDN cDNA Clone |
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MBS1275682-001mgPlasmid02mLGlycerolStock | MyBiosource | 0.01mgPlasmid+0.2mLGlycerol-Stock | EUR 200 |
PLDN cDNA Clone |
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MBS1275682-5x001mgPlasmid5x02mLGlycerolStock | MyBiosource | 5x0.01mgPlasmid+5x0.2mLGlycerol-Stock | EUR 855 |
PLDN cloning plasmid |
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CSB-CL890745HU-10ug | Cusabio | 10ug | EUR 279.6 |
Description: A cloning plasmid for the PLDN gene. |
PLDN Blocking Peptide |
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33R-2437 | Fitzgerald | 100 ug | EUR 119 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PLDN antibody, catalog no. 70R-2858 |
PLDN Blocking Peptide |
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33R-6524 | Fitzgerald | 100 ug | EUR 119 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PLDN antibody, catalog no. 70R-2857 |
PLDN Blocking Peptide |
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DF12041-BP | Affbiotech | 1mg | EUR 234 |
PLDN Blocking Peptide |
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MBS9620746-1mg | MyBiosource | 1mg | EUR 380 |
PLDN Blocking Peptide |
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MBS9620746-5x1mg | MyBiosource | 5x1mg | EUR 1650 |
PLDN (Pallidin) mouse monoclonal antibody, clone OTI1E2 (formerly 1E2) |
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TA504156 | Origene Technologies GmbH | 100 µl | Ask for price |
PLDN (Pallidin) mouse monoclonal antibody, clone OTI1E2 (formerly 1E2) |
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TA504156S | Origene Technologies GmbH | 30 µl | Ask for price |
PLDN (Pallidin) mouse monoclonal antibody, clone OTI1H9 (formerly 1H9) |
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TA504279 | Origene Technologies GmbH | 100 µl | Ask for price |
PLDN (Pallidin) mouse monoclonal antibody, clone OTI1H9 (formerly 1H9) |
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TA504279S | Origene Technologies GmbH | 30 µl | Ask for price |
PLDN protein (His tag) |
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80R-2215 | Fitzgerald | 50 ug | EUR 329 |
Description: Purified recombinant Human PLDN Protein (His tag) |
PLDN ELISA KIT|Human |
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EF001846 | Lifescience Market | 96 Tests | EUR 826.8 |
PLDN Peptide - middle region |
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MBS3236872-01mg | MyBiosource | 0.1mg | EUR 180 |
PLDN Peptide - middle region |
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MBS3236872-5x01mg | MyBiosource | 5x0.1mg | EUR 730 |
PLDN Recombinant Protein (Rat) |
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RP220886 | ABM | 100 ug | Ask for price |
PLDN Recombinant Protein (Human) |
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RP023749 | ABM | 100 ug | Ask for price |
PLDN Recombinant Protein (Mouse) |
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RP162719 | ABM | 100 ug | Ask for price |
Recombinant Human Pallidin (PLDN) |
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MBS1378826-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1095 |
Recombinant Human Pallidin (PLDN) |
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MBS1378826-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 685 |
Recombinant Human Pallidin (PLDN) |
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MBS1378826-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 845 |
Recombinant Human Pallidin (PLDN) |
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MBS1378826-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 800 |
Recombinant Human Pallidin (PLDN) |
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MBS1378826-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 990 |
Recombinant Mouse Pallidin (Pldn) |
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MBS1298087-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1095 |
Recombinant Mouse Pallidin (Pldn) |
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MBS1298087-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 685 |
Recombinant Mouse Pallidin (Pldn) |
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MBS1298087-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 845 |
Recombinant Mouse Pallidin (Pldn) |
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MBS1298087-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 800 |
Recombinant Mouse Pallidin (Pldn) |
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MBS1298087-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 990 |
Pldn ORF Vector (Rat) (pORF) |
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ORF073630 | ABM | 1.0 ug DNA | EUR 607.2 |
PLDN ORF Vector (Human) (pORF) |
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ORF007917 | ABM | 1.0 ug DNA | EUR 114 |
Pldn ORF Vector (Mouse) (pORF) |
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ORF054241 | ABM | 1.0 ug DNA | EUR 607.2 |
Rat Pallidin (PLDN) ELISA Kit |
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MBS9312472-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Rat Pallidin (PLDN) ELISA Kit |
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MBS9312472-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Rat Pallidin (PLDN) ELISA Kit |
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MBS9312472-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Rat Pallidin (PLDN) ELISA Kit |
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MBS9312472-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Human Pallidin (PLDN)ELISA kit |
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201-12-2524 | Shanghai Sunred Biological Technology | 96 tests | EUR 528 |
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Human Pallidin, PLDN ELISA KIT |
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ELI-21687h | Lifescience Market | 96 Tests | EUR 988.8 |
Mouse Pallidin, Pldn ELISA KIT |
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ELI-36376m | Lifescience Market | 96 Tests | EUR 1038 |
Mouse Pallidin (PLDN) ELISA Kit |
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MBS9311674-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Mouse Pallidin (PLDN) ELISA Kit |
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MBS9311674-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Mouse Pallidin (PLDN) ELISA Kit |
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MBS9311674-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Mouse Pallidin (PLDN) ELISA Kit |
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MBS9311674-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Human Pallidin, PLDN ELISA Kit |
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MBS9334061-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Human Pallidin, PLDN ELISA Kit |
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MBS9334061-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Human Pallidin, PLDN ELISA Kit |
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MBS9334061-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Human Pallidin, PLDN ELISA Kit |
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MBS9334061-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Human Pallidin (PLDN) ELISA Kit |
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MBS9304192-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Human Pallidin (PLDN) ELISA Kit |
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MBS9304192-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Human Pallidin (PLDN) ELISA Kit |
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MBS9304192-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Human Pallidin (PLDN) ELISA Kit |
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MBS9304192-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Mouse Pallidin, PLDN ELISA Kit |
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MBS9327417-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Mouse Pallidin, PLDN ELISA Kit |
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MBS9327417-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Mouse Pallidin, PLDN ELISA Kit |
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MBS9327417-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Mouse Pallidin, PLDN ELISA Kit |
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MBS9327417-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Human Pallidin (PLDN)ELISA kit |
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YLA3193HU-48T | Shanghai YL Biotech | 48T | Ask for price |
Human Pallidin (PLDN)ELISA kit |
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YLA3193HU-96T | Shanghai YL Biotech | 96T | Ask for price |
PLDN, 1-172aa, Human, His tag, E Coli |
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MBS204188-001mg | MyBiosource | 0.01mg | EUR 215 |
PLDN, 1-172aa, Human, His tag, E Coli |
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MBS204188-005mg | MyBiosource | 0.05mg | EUR 340 |
PLDN, 1-172aa, Human, His tag, E Coli |
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MBS204188-025mg | MyBiosource | 0.25mg | EUR 765 |
PLDN, 1-172aa, Human, His tag, E Coli |
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MBS204188-5x025mg | MyBiosource | 5x0.25mg | EUR 3195 |
Human Pallidi, PLDN GENLISA ELISA |
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KBH2523 | Krishgen | 1 x 96 wells | EUR 286 |
PLDN Peptide - N-terminal region |
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MBS3236871-01mg | MyBiosource | 0.1mg | EUR 180 |
PLDN Peptide - N-terminal region |
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MBS3236871-5x01mg | MyBiosource | 5x0.1mg | EUR 730 |
Recombinant Human PLDN, His-tagged |
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PLDN-1772H | Creative BioMart | 25ug | EUR 255.2 |
Description: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
PLDN Over-expression Lysate Product |
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GWB-F41633 | GenWay Biotech | 0.1 mg | Ask for price |
Carrier-free (BSA/glycerol-free) PLDN mouse monoclonal antibody, clone OTI1E2 (formerly 1E2) |
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CF504156 | Origene Technologies GmbH | 100 µg | Ask for price |
Carrier-free (BSA/glycerol-free) PLDN mouse monoclonal antibody, clone OTI1H9 (formerly 1H9) |
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CF504279 | Origene Technologies GmbH | 100 µg | Ask for price |
Pldn sgRNA CRISPR Lentivector set (Rat) |
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K7200301 | ABM | 3 x 1.0 ug | EUR 406.8 |
PLDN sgRNA CRISPR Lentivector set (Human) |
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K1664801 | ABM | 3 x 1.0 ug | EUR 406.8 |
Pldn sgRNA CRISPR Lentivector set (Mouse) |
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K3722301 | ABM | 3 x 1.0 ug | EUR 406.8 |