
Berberine Inhibits the gene Expression and Production of Proinflammatory Cytokines by Mononuclear cells in Rheumatoid Arthritis and Healthy Individuals
- Objective: Rheumatoid arthritis (RA) is the most prevalent autoimmune arthritis. Berberine is an alkaloid isolated from Berberis vulgaris and its anti-inflammatory effect has been identified.
- Method: Twenty newly diagnosed RA patients and 20 healthy controls participated. Peripheral mononuclear cells were prepared and stimulated with bacterial lipopolysachharide (LPS,1 µg/ml), exposed to different concentrations of berberine (10 and 50µM) and dexamethasone (10-7 M) as a reference. Toxicity of compounds was evaluated by WST-1 assay. Expression of TNF-α and IL-1β were determined by quantitative real-time PCR. Protein level of secreted TNF-α and IL1β were measured by using ELISA.
- Result: Berberine did not have any toxic effect on cells, whereas Lipopolysachharide (LPS) stimulation caused a noticeable rise in TNF-α and IL-1β production. Berberine markedly downregulated the expression of both TNF-α and IL1β and inhibits TNF-α and IL-1β secretion from LPS-stimulated PBMCs.
- Discussion: This study provided molecular basis for anti-inflammatory effect of berberine on human mononuclear cells through the suppression of TNF-a and IL-1secretion. Our findings highlighted the significant inhibitory effect of berberine on proinflammatory responses of mononuclear cells from rheumatoid arthritis individuals, which may be responsible for antiinflammatory property of Barberry. We observed that berberine at high concentration exhibited anti-inflammatory effect in PBMCs of both healthy and patient groups by suppression of TNF-a and IL-1cytokines at both mRNA and protein levels.
- Conclusions: Berberine may inhibit the gene expression and production of pro-inflammatory cytokines by mononuclear cells in rheumatoid arthritis and healthy individuals without affecting cells viability. Future studies with larger sample size is needed to prove the idea.
Parainfluenza Type-2 Protein |
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30-1996 | Fitzgerald | 50 ug | EUR 280.8 |
Description: Purified Parainfluenza type 2 protein |
Parainfluenza type 2 antibody (FITC) |
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61C-CR3015M1F | Fitzgerald | 100 ug | EUR 553.2 |
Description: Mouse monoclonal Parainfluenza type 2 antibody (FITC) |
Parainfluenza type 2 protein |
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30-AP53 | Fitzgerald | 1 ml | EUR 489.6 |
Description: Purified Parainfluenza type 2 protein |
Parainfluenza Virus, Canine Antigen |
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DAGA-513 | Creative Diagnostics | 1mg | EUR 1263.6 |
Parainfluenza Type 2&3 Antibody (HRP) |
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abx023112-1ml | Abbexa | 1 ml | EUR 718.8 |
Parainfluenza type 1 antibody |
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10-P43A | Fitzgerald | 1 mg | EUR 609.6 |
Description: Mouse monoclonal Parainfluenza type 1 antibody |
Parainfluenza type 1 antibody |
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10-P43B | Fitzgerald | 1 mg | EUR 588 |
Description: Mouse monoclonal Parainfluenza type 1 antibody |
Parainfluenza type 1 antibody |
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10-P43D | Fitzgerald | 1 mg | EUR 159.6 |
Description: Mouse monoclonal Parainfluenza type 1 antibody |
Parainfluenza type 3 antibody |
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10-P63A | Fitzgerald | 1 mg | EUR 537.6 |
Description: Mouse monoclonal Parainfluenza type 3 antibody |
Parainfluenza type 3 antibody |
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10-P63B | Fitzgerald | 1 mg | EUR 537.6 |
Description: Mouse monoclonal Parainfluenza type 3 antibody |
Parainfluenza type 3 antibody |
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10-P63C | Fitzgerald | 1 mg | EUR 418.8 |
Description: Mouse monoclonal Parainfluenza type 3 antibody |
Parainfluenza type 3 antibody |
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10C-CR3016M1 | Fitzgerald | 100 ug | EUR 489.6 |
Description: Mouse monoclonal Parainfluenza type 3 antibody |
Parainfluenza type 3 antibody |
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10C-CR3016M2 | Fitzgerald | 100 ug | EUR 163.2 |
Description: Mouse monoclonal Parainfluenza type 3 antibody |
Parainfluenza type 3 antibody |
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10C-CR3016M3 | Fitzgerald | 100 ug | EUR 163.2 |
Description: Mouse monoclonal Parainfluenza type 3 antibody |
Parainfluenza type 1 antibody |
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20-PG89 | Fitzgerald | 1 mg | EUR 139.2 |
Description: Goat polyclonal Parainfluenza type 1 antibody |
Parainfluenza Type 1 Antibody |
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abx022123-1mg | Abbexa | 1 mg | EUR 994.8 |
Parainfluenza Type 3 Antibody |
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abx022126-1mg | Abbexa | 1 mg | EUR 994.8 |
Parainfluenza Type 3 Antibody |
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abx022127-1mg | Abbexa | 1 mg | EUR 994.8 |
Parainfluenza Type 1 Antibody |
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abx022128-1mg | Abbexa | 1 mg | EUR 777.6 |
Parainfluenza Type 3 Antibody |
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abx022130-1mg | Abbexa | 1 mg | EUR 777.6 |
Parainfluenza Virus Type-2 |
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7-07954 | CHI Scientific | 10µg | Ask for price |
Parainfluenza Virus Type-2 |
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7-07955 | CHI Scientific | 50µg | Ask for price |
Parainfluenza Virus Type-2 |
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7-07956 | CHI Scientific | 1mg | Ask for price |
Parainfluenza type 1 + 3 antibody |
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10-P43C | Fitzgerald | 1 mg | EUR 523.2 |
Description: Mouse monoclonal Parainfluenza type 1 + 3 antibody |
Parainfluenza Type 1&3 Antibody |
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abx022122-1mg | Abbexa | 1 mg | EUR 994.8 |
Parainfluenza type 3 antibody (FITC) |
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61C-CR3016M2F | Fitzgerald | 100 ug | EUR 553.2 |
Description: Mouse monoclonal Parainfluenza type 3 antibody (FITC) |
Parainfluenza Type-1 protein |
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30-1995 | Fitzgerald | 50 ug | EUR 295.2 |
Description: Purified Parainfluenza type 1 protein |
Parainfluenza Type-3 Protein |
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30-1997 | Fitzgerald | 50 ug | EUR 295.2 |
Description: Purified Parainfluenza type 3 protein |
Parainfluenza type 1 protein |
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30-AP43 | Fitzgerald | 1 ml | EUR 508.8 |
Description: Purified Parainfluenza type 1 protein |
Parainfluenza type 3 protein |
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30-AP63 | Fitzgerald | 1 ml | EUR 489.6 |
Description: Purified Parainfluenza type 3 protein |
Parainfluenza Virus Type-2 Protein |
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20-abx260514 | Abbexa |
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Parainfluenza Virus Type-1 |
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7-07951 | CHI Scientific | 10µg | Ask for price |
Parainfluenza Virus Type-1 |
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7-07952 | CHI Scientific | 50µg | Ask for price |
Parainfluenza Virus Type-1 |
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7-07953 | CHI Scientific | 1mg | Ask for price |
Parainfluenza Virus Type-3 |
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7-07957 | CHI Scientific | 10µg | Ask for price |
Parainfluenza Virus Type-3 |
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7-07958 | CHI Scientific | 50µg | Ask for price |
Parainfluenza Virus Type-3 |
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7-07959 | CHI Scientific | 1mg | Ask for price |
Monoclonal Anti-Sendai virus/Parainfluenza type 3 (SeV/Parainfluenza virus 3) IgG |
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SEND31-M | Alpha Diagnostics | 100 ug | EUR 578.4 |
Mouse antibody for Parainfluenza virus type 2 |
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1241 | Virostat | 100 ug | EUR 386.26 |
Description: This is purified Mouse monoclonal antibody against Parainfluenza virus type 2 for WB, ELISA. |
Parainfluenza Virus Type-1 Protein |
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20-abx260513 | Abbexa |
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Parainfluenza Virus Type-3 Protein |
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20-abx260515 | Abbexa |
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Monoclonal Anti-Sendai virus/Parainfluenza type 1 fusion protein F (SeV/Parainfluenza virus 1, F) IgG |
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SENF14-M | Alpha Diagnostics | 100 ug | EUR 578.4 |
Monoclonal Anti-Sendai virus/Parainfluenza type 3 hemagluttinin (HA) protein (SeV/Parainfluenza virus 3, H) IgG (clone 2) |
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SENH33-M | Alpha Diagnostics | 100 ug | EUR 578.4 |
Mouse antibody for Parainfluenza virus type 1 |
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1221 | Virostat | 100 ug | EUR 386.26 |
Description: This is purified Mouse monoclonal antibody against Parainfluenza virus type 1 for WB, ELISA. |
Mouse antibody for Parainfluenza virus type 1 |
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1224 | Virostat | 100 ug | EUR 386.26 |
Description: This is purified Mouse monoclonal antibody against Parainfluenza virus type 1 for WB, ELISA. |
Mouse antibody for Parainfluenza virus type 1 |
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1226 | Virostat | 100 ug | EUR 386.26 |
Description: This is purified Mouse monoclonal antibody against Parainfluenza virus type 1 for WB, ELISA. |
Mouse antibody for Parainfluenza virus type 1 |
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1231 | Virostat | 100 ug | EUR 386.26 |
Description: This is purified Mouse monoclonal antibody against Parainfluenza virus type 1 for WB, ELISA. |
Mouse antibody for Parainfluenza virus type 3 |
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1254 | Virostat | 100 ug | EUR 386.26 |
Description: This is purified Mouse monoclonal antibody against Parainfluenza virus type 3 for WB, ELISA. |
Mouse antibody for Parainfluenza virus type 3 |
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1256 | Virostat | 100 ug | EUR 386.26 |
Description: This is purified Mouse monoclonal antibody against Parainfluenza virus type 3 for WB, ELISA. |
Mouse antibody for Parainfluenza virus type 3 |
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1258 | Virostat | 100 ug | EUR 386.26 |
Description: This is purified Mouse monoclonal antibody against Parainfluenza virus type 3 for WB, ELISA. |
Sendai virus/Parainfluenza type 1 antigens (Vero cells, inactivated, partially pure) for ELISA/Western |
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SEND15-N-100 | Alpha Diagnostics | 100 ul | EUR 416.4 |
Sendai virus/Parainfluenza type 3 antigens (Vero cells, inactivated, partially pure) for ELISA/Western |
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SEND35-N-100 | Alpha Diagnostics | 100 ul | EUR 416.4 |
Monoclonal Anti-Sendai virus/Parainfluenza type 3 hemagluttinin (HA) protein (SeV/Parainfluenza virus 3, H) IgG (clone 1) |
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SENH32-M | Alpha Diagnostics | 100 ug | EUR 578.4 |
Sendai virus/Parainfluenza type 2 antigens (Vero cells, inactivated, partially pure) for ELISA/Western, Quantitative |
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SEND25-N-100 | Alpha Diagnostics | 100 ul | EUR 416.4 |
NATtrol Parainfluenza Virus Type 2 Stock (Qualitative) (1 mL) |
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NATPARA2-ST | Zeptometrix | 1 mL | EUR 1281 |
Recombinant Influenza Parainfluenza Type-2 Protein, Untagged, E.coli-10ug |
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QP12960-10ug | EnQuireBio | 10ug | EUR 186 |
Recombinant Influenza Parainfluenza Type-2 Protein, Untagged, E.coli-1mg |
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QP12960-1mg | EnQuireBio | 1mg | EUR 2470.8 |
Recombinant Influenza Parainfluenza Type-2 Protein, Untagged, E.coli-50ug |
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QP12960-50ug | EnQuireBio | 50ug | EUR 241.2 |
Parainfluenza 1 antibody |
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10-2841 | Fitzgerald | 1 mg | EUR 798 |
Description: Parainfluenza type 1 antibody |
Parainfluenza 1 Antibody |
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abx022121-1mg | Abbexa | 1 mg | EUR 1296 |
Parainfluenza 1 Antibody |
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abx023109-1ml | Abbexa | 1 ml | EUR 644.4 |
NATtrol Parainfluenza Virus Type 1 Stock (Qualitative) (1 mL) |
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NATPARA1-ST | Zeptometrix | 1 mL | EUR 1281 |
NATtrol Parainfluenza Virus Type 3 Stock (Qualitative) (1 mL) |
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NATPARA3-ST | Zeptometrix | 1 mL | EUR 1281 |
NATtrol Parainfluenza Virus Type 4 Stock (Qualitative) (1 mL) |
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NATPARA4-ST | Zeptometrix | 1 mL | EUR 1281 |
Recombinant Influenza Parainfluenza Type-1 Protein, Untagged, E.coli-10ug |
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QP12959-10ug | EnQuireBio | 10ug | EUR 186 |
Recombinant Influenza Parainfluenza Type-1 Protein, Untagged, E.coli-1mg |
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QP12959-1mg | EnQuireBio | 1mg | EUR 2470.8 |
Recombinant Influenza Parainfluenza Type-1 Protein, Untagged, E.coli-50ug |
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QP12959-50ug | EnQuireBio | 50ug | EUR 241.2 |
Recombinant Influenza Parainfluenza Type-3 Protein, Untagged, E.coli-10ug |
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QP12961-10ug | EnQuireBio | 10ug | EUR 186 |
Recombinant Influenza Parainfluenza Type-3 Protein, Untagged, E.coli-1mg |
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QP12961-1mg | EnQuireBio | 1mg | EUR 2470.8 |
Recombinant Influenza Parainfluenza Type-3 Protein, Untagged, E.coli-50ug |
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QP12961-50ug | EnQuireBio | 50ug | EUR 241.2 |
Parainfluenza 1/2/3 IgA ELISA kit |
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55R-IB79268 | Fitzgerald | 96 wells | EUR 379.2 |
Description: ELISA kit for the detection of Parainfluenza 1/2/3 IgA in the research laboratory |
Parainfluenza 1/2/3 IgG ELISA kit |
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55R-IB79269 | Fitzgerald | 96 wells | EUR 379.2 |
Description: ELISA kit for the detection of Parainfluenza 1/2/3 IgG in the research laboratory |
Parainfluenza 1/2/3 IgM ELISA kit |
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55R-IB79270 | Fitzgerald | 96 wells | EUR 379.2 |
Description: ELISA kit for the detection of Parainfluenza 1/2/3 IgM in the research laboratory |
Parainfluenza 1/2/3 IgM ELISA Kit |
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DEIA1949 | Creative Diagnostics | 96T | EUR 972 |
Description: The Parainfluenza 1/2/3 IgG ELISA has been designed for measurement of specific IgM antibodies respectively against Parainfluenza virus type 1/2/3 in serum and plasma. Further applications in other body fluids are possible and can be provided on request. |
Parainfluenza 1/2/3 IgG ELISA Kit |
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DEIA369 | Creative Diagnostics | 96T | EUR 674.4 |
Description: The Parainfluenza 1/2/3 IgG antibody ELISA kit has been designed for the detectionand the quantitative determination of specific IgG antibodies against Parainfluenza 1/2/3 in serum and plasma. |
Parainfluenza 1/2/3 IgA ELISA Kit |
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DEIA370 | Creative Diagnostics | 96T | EUR 674.4 |
Description: The Parainfluenza 1/2/3 IgA antibody ELISA kit has been designed for the detection and the quantitative determination of specific IgA antibodies against Parainfluenza 1/2/3 in serum and plasma. |
Parainfluenza 1/2/3 IgM ELISA Kit |
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DEIA371 | Creative Diagnostics | 96T | EUR 674.4 |
Description: The Parainfluenza 1/2/3 IgM antibody ELISA kit has been designed for the detection and the quantitative determination of specific IgM antibodies against Parainfluenza 1/2/3 in serum and plasma. |
Parainfluenza 2, Strain GREER Protein |
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abx069897-1ml | Abbexa | 1 ml | EUR 794.4 |
Human Parainfluenza Virus 2 (HPIV-2) Antibody |
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abx411532-01mg | Abbexa | 0.1 mg | EUR 760.8 |
Canine Parainfluenza protein |
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30-1253 | Fitzgerald | 1 mg | EUR 548.4 |
Description: Purified native Canine Parainfluenza protein |
Virus Parainfluenza Virus 2 (HPIV-2) Protein |
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abx670266-1ml | Abbexa | 1 ml | EUR 710.4 |
Human Parainfluenza Virus 2/3 (HPIV-2/3) Antibody |
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abx411533-1ml | Abbexa | 1 ml | EUR 610.8 |
Mouse antibody for Parainfluenza virus |
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1233 | Virostat | 100 ug | EUR 431.93 |
Description: This is Mouse monoclonal FITC conjugated antibody against Parainfluenza virus type 1 for WB, ELISA. |
Mouse antibody for Parainfluenza virus |
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1243 | Virostat | 100 ug | EUR 431.93 |
Description: This is Mouse monoclonal FITC conjugated antibody against Parainfluenza virus type 2 for WB, ELISA. |
Mouse antibody for Parainfluenza virus |
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1259 | Virostat | 100 ug | EUR 431.93 |
Description: This is Mouse monoclonal FITC conjugated antibody against Parainfluenza virus type 3 for WB, ELISA. |
Human parainfluenza virus PCR kit |
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PCR-H445-48R | Bioingentech | 50T | EUR 987.6 |
Human parainfluenza virus PCR kit |
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PCR-H445-96R | Bioingentech | 100T | EUR 1335.6 |
Canine parainfluenza virus PCR kit |
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PCR-V112-48R | Bioingentech | 50T | EUR 987.6 |
Canine parainfluenza virus PCR kit |
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PCR-V112-96R | Bioingentech | 100T | EUR 1335.6 |
Parainfluenza 3 Strain III Protein |
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abx060639-1mg | Abbexa | 1 mg | EUR 2080.8 |
Parainfluenza 1 Strain VP1 Protein |
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abx069896-1ml | Abbexa | 1 ml | EUR 878.4 |
Recombinant (yeast) Parainfluenza type 1 nucelocapsid protein (C35, full length, >95%, ~60 kda) |
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SENN15-R-10 | Alpha Diagnostics | 10 ug | EUR 416.4 |
Mouse Anti Parainfluenza Virus 2 Monoclonal Antibody |
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DMABT-51480MP | Creative Diagnostics | 0.1 mg | EUR 1070.4 |
Mouse Anti Parainfluenza Virus 2 Monoclonal Antibody |
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DMABT-51481MP | Creative Diagnostics | 0.1 mg | EUR 1070.4 |
Human parainfluenza virus RT PCR kit |
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RTq-H445-100R | Bioingentech | 100T | EUR 1573.2 |
Human parainfluenza virus RT PCR kit |
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RTq-H445-150R | Bioingentech | 150T | EUR 2144.4 |
Human parainfluenza virus RT PCR kit |
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RTq-H445-50R | Bioingentech | 50T | EUR 1155.6 |
Parainfluenza 3, Strain C243 Protein |
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abx069898-1ml | Abbexa | 1 ml | EUR 794.4 |
Parainfluenza virus Antibody IgA ELISA Kit |
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DEIA1857 | Creative Diagnostics | 96T | EUR 867.6 |
Description: The Parainfluenza virus Antibody IgA ELISA Kit is intended for measurement of IgA class antibodies against Parainfluenza Virus IgA in human serum or plasma (citrate). |
Goat polyclonal antibody for Parainfluenza |
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1204 | Virostat | 1 ml | EUR 373.2 |
Description: This is HRP conjugated goat polyclonal antibody against Parainfluenza type 1 for WB, ELISA. |
Goat polyclonal antibody for Parainfluenza |
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1207 | Virostat | 1 ml | EUR 347.1 |
Description: This is Biotin conjugated goat polyclonal antibody against Parainfluenza types 2 & 3 for WB, ELISA. |
Goat polyclonal antibody for Parainfluenza |
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1211 | Virostat | 1 ml | EUR 327.53 |
Description: This is goat polyclonal antibody against Parainfluenza type 1 for WB, ELISA. |
Goat polyclonal antibody for Parainfluenza |
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1217 | Virostat | 1 ml | EUR 347.1 |
Description: This is Biotin conjugated goat polyclonal antibody against Parainfluenza type 1 for WB, ELISA. |
Goat polyclonal antibody for Parainfluenza |
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1201 | Virostat | 1 ml | EUR 327.53 |
Description: This is goat polyclonal antibody against Parainfluenza types 2 & 3 for WB, ELISA. |
Canine parainfluenza virus RT PCR kit |
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RTq-V112-100R | Bioingentech | 100T | EUR 1573.2 |
Canine parainfluenza virus RT PCR kit |
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RTq-V112-150R | Bioingentech | 150T | EUR 2144.4 |
Canine parainfluenza virus RT PCR kit |
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RTq-V112-50R | Bioingentech | 50T | EUR 1155.6 |
Parainfluenza 1 Strain Sendai Protein |
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abx060637-1mg | Abbexa | 1 mg | EUR 2030.4 |
Human Parainfluenza Virus (PIV) ELISA Kit |
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abx052868-96tests | Abbexa | 96 tests | EUR 801.6 |
NATtrol Parainfluenza Control (6 X 0.5mL) |
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NATPIV-ERC | Zeptometrix | 6 X 0.5mL | EUR 265 |
Goat Anti-Human Parainfluenza 2 & 3 Polyclonal Antibody |
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DPAB0162 | Creative Diagnostics | 1 ml | EUR 889.2 |
Goat Anti-Human Parainfluenza 2 & 3 Polyclonal Antibody |
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DPAB0134 | Creative Diagnostics | 1 ml | EUR 889.2 |
Goat Anti Parainfluenza 1 Polyclonal Antibody |
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DPBT-66910GP | Creative Diagnostics | 1 ml | EUR 1008 |
Goat Anti-Sendai (Sev/Parainfluenza virus 2/3) antiserum |
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SEND23-S | Alpha Diagnostics | 100 ul | EUR 548.4 |
Human Parainfluenza Virus 3 (HPIV-3) Antibody |
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abx411110-01mg | Abbexa | 0.1 mg | EUR 526.8 |
Human Parainfluenza Virus 1 (HPIV-1) Antibody |
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abx415708-1ml | Abbexa | 1 ml | EUR 727.2 |
Human Parainfluenza Virus 1 (HPIV-1) Antibody |
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abx414520-1mg | Abbexa | 1 mg | EUR 994.8 |
Human Parainfluenza Virus 3 (HPIV-3) Antibody |
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abx414521-1mg | Abbexa | 1 mg | EUR 994.8 |
Goat Anti Human Parainfluenza Virus 2/3 Polyclonal Antibody |
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DPBT-66911GH | Creative Diagnostics | 1 ml | EUR 920.4 |
Brain Network Connectivity and Association with Catechol-O-Methyltransferase Gene Polymorphism in Korean Attention-Deficit Hyperactivity Disorder Children
Objective: We sought to determine if the links between and within the default mode network (DMN) and dorsal attention network (DAT) exhibited different conditions according to catechol-O-methyltransferase (COMT) gene polymorphism in relationship to attention-deficit hyperactivity disorder (ADHD) symptoms.
Methods: Fifty-seven children with ADHD and 48 healthy controls (HCs) were administered an intelligence test, the Children’s Depression Inventory, the Korean ADHD rating scale, and continuous performance test. Resting-state brain functional MRI scans were obtained, and COMT genotyping was performed to distinguish valine carriers and methionine homozygotes.
Results: Compared to controls, children with ADHD showed increased ADHD scale scores, increased visual commission errors, and increased functional connectivity (FC) within the DMN and DAT. Compared to all children with ADHD, children with the methionine homozygote and those who were valine carriers showed increased FC within the DMN and DAT and decreased FC between the DMN and DAT. FC within the DMN was also increased in HC valine carriers compared to HC children with the methionine homozygote, and in children with ADHD who were valine carriers compared to HC valine carriers.
Conclusion: We observed increased brain connectivity within the DMN and DAT and altered brain connectivity within and between the DMN and DAT associated with COMT polymorphism in children with ADHD.
Ovarian cancer predisposition beyond BRCA1 and BRCA2 genes
Several genes associated with hereditary ovarian cancer have been discovered as a result of the work done with next generation sequencing. It is estimated that approximately 23% of ovarian carcinomas have a hereditary predisposition. The most common hereditary condition is represented by germline mutations in BRCA1 or BRCA2 genes that account for 20-25% of high grade serous ovarian cancer.
A number of other hereditary ovarian cancers are associated with different genes, with a crucial role in the DNA damage response pathway, such as the mismatch repair genes in Lynch syndrome, TP53 in Li-Fraumeni syndrome, STK11 in Peutz-Jeghers syndrome, CHEK2, RAD51, BRIP1, and PALB2. The goal of this manuscript is to summarize the published data regarding the molecular pathways involved in the pathogenesis of non-BRCA related hereditary ovarian cancer and to provide a tool that might be useful in discussing risk assessment, genetic testing, prevention strategies, as well as clinical and therapeutic implications for patients with ovarian cancer.
Transcriptome analysis of duck embryo fibroblasts for the dynamic response to duck tembusu virus infection and dual regulation of apoptosis genes
Duck Tembusu virus (DTMUV) is an emerging pathogenic flavivirus that has caused enormous economic losses in Southeast Asia. However, the pathogenic mechanism and host’s responses after DTMUV infection remain poorly understood. During this study, total mRNA sequencing (RNA-Seq) analysis was used to detect the global gene expression in DEFs at various time points after DTMUV infection.
We identified 326 genes altered significantly at all time points, and these genes were dynamically enriched in multifarious biological processes, including apoptosis, innate immune response, DNA replication, cell cycle arrest and DNA repair. Next, the results showed that apoptosis was induced and the proportion of apoptosis increased with time, and pro-apoptotic molecules caspases were activated.
The RNA-seq data analysis further revealed that most pro-apoptosis and anti-apoptosis genes were early continually responsive, and the genes involved in both intrinsic and extrinsic apoptotic pathways were initiated. Further, the considerably enriched immune-relevant pathways were involved in apoptosis process, and protein-protein interactions (PPIs) analysis showed that IL6, STAT1, TNFAIP3, CFLAR and PTGS2 may be key regulators of DEFs apoptosis. In conclusion, this study not only contributes to understanding the underlying mechanism of DEFs infection with DTMUV, but also provides new insights into targets screening for antiviral therapy.
SS-B Antigen |
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E61A00401 | EnoGene | 1mg | EUR 1230 |
SS-B Antigen Antibody |
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abx022700-2ml | Abbexa | 2 ml | EUR 543.6 |
SS-A (Ro) Protein |
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abx069943-1000Units | Abbexa | 1000 Units | EUR 2180.4 |
SS-A (Ro) Protein |
|||
abx069944-02mg | Abbexa | 0.2 mg | EUR 1513.2 |
Human SS-A/Ro antibody(Anti-Ro)ELISA Kit |
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GA-E0502HM-48T | GenAsia Biotech | 48T | EUR 346.8 |
Human SS-A/Ro antibody(Anti-Ro)ELISA Kit |
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GA-E0502HM-96T | GenAsia Biotech | 96T | EUR 559.2 |
Human SS-A/Ro antibody(Anti-Ro)ELISA Kit |
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QY-E02678 | Qayee Biotechnology | 96T | EUR 433.2 |
Protein A Antigen |
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E61I01601 | EnoGene | 100ug | EUR 411.6 |
Protein A Antigen |
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IM124 | Cygnus Technologies | 1 ml | EUR 342 |
Description: Protein A Antigen by Cygnus Technologies is available in Europe via Gentaur. |
Rat Anti-SS-A/Ro ELISA Kit |
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ERS0293 | Abclonal | 96Tests | EUR 625.2 |
Rat SS A/Ro antibody ELISA kit |
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E02S0286-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Rat SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat SS A/Ro antibody ELISA kit |
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E02S0286-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Rat SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat SS A/Ro antibody ELISA kit |
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E02S0286-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Rat SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig SS A/Ro antibody ELISA kit |
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E07S0286-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Porcine SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig SS A/Ro antibody ELISA kit |
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E07S0286-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Porcine SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig SS A/Ro antibody ELISA kit |
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E07S0286-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Porcine SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog SS A/Ro antibody ELISA kit |
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E08S0286-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Canine SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog SS A/Ro antibody ELISA kit |
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E08S0286-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Canine SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog SS A/Ro antibody ELISA kit |
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E08S0286-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Canine SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Anti-SS-A/Ro ELISA Kit |
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EGTS0293 | Abclonal | 96Tests | EUR 625.2 |
SS-A (Ro) Antibody IgG ELISA Kit |
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DEIA1685 | Creative Diagnostics | 96T | EUR 928.8 |
Description: Anti-SS-A is an indirect solid phase enzyme immunoassay (ELISA) for the quantitative measurement of IgG class autoantibodies against SS-A (Ro, 52 and 60 kDa) in human serum or plasma. |
Mouse Anti-SS-A/Ro ELISA Kit |
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EMS0293 | Abclonal | 96Tests | EUR 625.2 |
Sheep Anti-SS-A/Ro ELISA Kit |
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ESS0293 | Abclonal | 96Tests | EUR 625.2 |
Goat SS A/Ro antibody ELISA kit |
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E06S0286-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Goat SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat SS A/Ro antibody ELISA kit |
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E06S0286-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Goat SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat SS A/Ro antibody ELISA kit |
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E06S0286-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Goat SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Anti-SS-A/Ro ELISA Kit |
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EHS0293 | Abclonal | 96Tests | EUR 625.2 |
Rabbit Anti-SS-A/Ro ELISA Kit |
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ERTS0293 | Abclonal | 96Tests | EUR 625.2 |
Monkey Anti-SS-A/Ro ELISA Kit |
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EMKS0293 | Abclonal | 96Tests | EUR 625.2 |
Mouse SS A/Ro antibody ELISA kit |
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E03S0286-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Mouse SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse SS A/Ro antibody ELISA kit |
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E03S0286-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Mouse SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse SS A/Ro antibody ELISA kit |
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E03S0286-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Mouse SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human SS A/Ro antibody ELISA kit |
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E01S0286-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Human SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human SS A/Ro antibody ELISA kit |
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E01S0286-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Human SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human SS A/Ro antibody ELISA kit |
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E01S0286-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Human SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human SS- A/ Ro antibody ELISA Kit |
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ELA-E0290h | Lifescience Market | 96 Tests | EUR 988.8 |
Bovine Anti-SS-A/Ro ELISA Kit |
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EBS0293 | Abclonal | 96Tests | EUR 625.2 |
Canine Anti-SS-A/Ro ELISA Kit |
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ECS0293 | Abclonal | 96Tests | EUR 625.2 |
Human SS-A/Ro antibody ELISA Kit |
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201-12-0486 | SunredBio | 96 tests | EUR 528 |
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Human SS-A/Ro antibody ELISA Kit |
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CN-03852H1 | ChemNorm | 96T | EUR 520.8 |
Human SS-A/Ro antibody ELISA Kit |
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CN-03852H2 | ChemNorm | 48T | EUR 340.8 |
Porcine Anti-SS-A/Ro ELISA Kit |
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EPS0293 | Abclonal | 96Tests | EUR 625.2 |
Rabbit SS A/Ro antibody ELISA kit |
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E04S0286-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Rabbit SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit SS A/Ro antibody ELISA kit |
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E04S0286-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Rabbit SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit SS A/Ro antibody ELISA kit |
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E04S0286-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Rabbit SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Chicken Anti-SS-A/Ro ELISA Kit |
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ECKS0293 | Abclonal | 96Tests | EUR 625.2 |
Monkey SS A/Ro antibody ELISA kit |
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E09S0286-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Monkey SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey SS A/Ro antibody ELISA kit |
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E09S0286-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Monkey SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey SS A/Ro antibody ELISA kit |
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E09S0286-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Monkey SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human SS-A/Ro antibody ELISA Kit |
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YLA2239HU-48T | Shanghai YL Biotech | 48T | EUR 435 |
Human SS-A/Ro antibody ELISA Kit |
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YLA2239HU-96T | Shanghai YL Biotech | 96T | EUR 562.5 |
Anserine SS-A/Ro antibody ELISA Kit |
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EAS0293 | Abclonal | 96Tests | EUR 625.2 |
Recombinant Human RO-52/SS-A |
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7-06166 | CHI Scientific | 10µg | Ask for price |
Recombinant Human RO-52/SS-A |
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7-06167 | CHI Scientific | 50µg | Ask for price |
Recombinant Human RO-52/SS-A |
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7-06168 | CHI Scientific | 1mg | Ask for price |
60 kDa SS-A / Ro ribonucleoprotein Antibody |
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20-abx109466 | Abbexa |
|
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Influenza A (H1N1) Antigen |
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11-553 | ProSci | 1 mL | EUR 645 |
Description: Influenza A, Influenza A (H1N1) |
Influenza A (H3N2) Antigen |
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11-554 | ProSci | 1 mL | EUR 645 |
Description: Influenza A Antigen Strain TX, Influenza A Antigen Strain Texas |
Influenza A H1N1 Antigen |
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abx670268-1ml | Abbexa | 1 ml | EUR 627.6 |
Leukocyte Antigen A (HLA-A) Antibody |
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abx233899-100ug | Abbexa | 100 ug | EUR 661.2 |
Leukocyte Antigen A (HLA-A) Antibody |
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20-abx141675 | Abbexa |
|
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Leukocyte Antigen A (HLA-A) Antibody |
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abx025201-100ul | Abbexa | 100 ul | EUR 627.6 |
Leukocyte Antigen A (HLA-A) Antibody |
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20-abx001779 | Abbexa |
|
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Leukocyte Antigen A (HLA-A) Antibody |
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abx145235-100ug | Abbexa | 100 ug | EUR 469.2 |
Inactivated HMPV A Antigen |
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VAng-Lsx0261-200L | Creative Biolabs | 200 µL | EUR 2334 |
Description: Inactivated Metapneumovirus A antigen by 4mM binary ethylinimine treatment. |
Protein A Antigen Concentrate |
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F603X | Cygnus Technologies | 250 ul | EUR 308.4 |
Description: Protein A Antigen Concentrate by Cygnus Technologies is available in Europe via Gentaur. |
Protein A Antigen Concentrate |
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F613X | Cygnus Technologies | 250 ul | EUR 262.8 |
Description: Protein A Antigen Concentrate by Cygnus Technologies is available in Europe via Gentaur. |
Protein A Antigen Concentrate |
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F044 | Cygnus Technologies | 200 ul | EUR 308.4 |
Description: Protein A Antigen Concentrate by Cygnus Technologies is available in Europe via Gentaur. |
Protein A Antigen Concentrate |
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F403H | Cygnus Technologies | 200 ul | EUR 308.4 |
Description: Protein A Antigen Concentrate by Cygnus Technologies is available in Europe via Gentaur. |
Guinea Pig Anti-SS-A/Ro ELISA Kit |
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EGS0293 | Abclonal | 96Tests | EUR 625.2 |
Human Anti-SS-A (RO-52) ELISA kit |
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YLA4157HU-48T | Shanghai YL Biotech | 48T | EUR 435 |
Human Anti-SS-A (RO-52) ELISA kit |
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YLA4157HU-96T | Shanghai YL Biotech | 96T | EUR 562.5 |
Guinea pig SS A/Ro antibody ELISA kit |
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E05S0286-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Guinea pig SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea pig SS A/Ro antibody ELISA kit |
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E05S0286-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Guinea pig SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea pig SS A/Ro antibody ELISA kit |
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E05S0286-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Guinea pig SS A/Ro antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Antigen 85-A Antibody (HRP) |
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20-abx109227 | Abbexa |
|
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60 kDa SS-A / Ro ribonucleoprotein Antibody (HRP) |
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20-abx107904 | Abbexa |
|
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60 kDa SS-A / Ro ribonucleoprotein Antibody (FITC) |
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20-abx106485 | Abbexa |
|
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60 kDa SS-A / Ro ribonucleoprotein Antibody (Biotin) |
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20-abx105070 | Abbexa |
|
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Antigen 85-A Antibody (FITC) |
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20-abx107809 | Abbexa |
|
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60 kDa SS-A/Ro ribonucleoprotein Polyclonal Antibody |
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42572-100ul | SAB | 100ul | EUR 399.6 |
Antigen 85-A (Ag85A) Antibody |
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20-abx110661 | Abbexa |
|
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Human 60KDA SS-A/Ro ribonucleoprotein (TROVE2) |
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1-CSB-EP025071HU1 | Cusabio |
|
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Description: Recombinant Human 60KDA SS-A/Ro ribonucleoprotein(TROVE2),partial expressed in E.coli |
Antigen 85-A Antibody (Biotin) |
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20-abx106397 | Abbexa |
|
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M. Tuberculosis 85-A Antigen |
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DAGA-181 | Creative Diagnostics | 100 µg | EUR 868.8 |
Influenza A Virus Antigen (H5N1) |
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VAng-Lsx011-1mL | Creative Biolabs | 1 mL | EUR 883.2 |
Description: Natural antigen of Influenza A virus subtype H5N1. |
Influenza A (H3N2) Antigen Protein |
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abx061421-1ml | Abbexa | 1 ml | EUR 718.8 |
JSR Protein A Antigen Concentrate |
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F743X | Cygnus Technologies | 0.3 ml | EUR 493.2 |
Description: JSR Protein A Antigen Concentrate by Cygnus Technologies is available in Europe via Gentaur. |
Pig Leukocyte Antigen A (HLA-A) ELISA Kit |
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abx361055-96tests | Abbexa | 96 tests | EUR 990 |
Recombinant Hepatitis B Virus Core Antigen (a. a. 183) |
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DAG593 | Creative Diagnostics | 1mg | EUR 1009.2 |
Human Leukocyte Antigen A (HLA-A) CLIA Kit |
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abx197215-96tests | Abbexa | 96 tests | EUR 990 |
Native Salmonella paratyphi A antigen |
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DAGA-3049 | Creative Diagnostics | 100ul | EUR 936 |
Human Leukocyte Antigen A (HLA-A) ELISA Kit |
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abx252628-96tests | Abbexa | 96 tests | EUR 848.4 |
Sheep Leukocyte Antigen A (HLA-A) ELISA Kit |
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abx364147-96tests | Abbexa | 96 tests | EUR 1111.2 |
Human leukocyte antigen A,HLA-A ELISA Kit |
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201-12-0445 | SunredBio | 96 tests | EUR 528 |
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Human leukocyte antigen A,HLA-A ELISA Kit |
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CN-04192H1 | ChemNorm | 96T | EUR 542.4 |
Human leukocyte antigen A,HLA-A ELISA Kit |
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CN-04192H2 | ChemNorm | 48T | EUR 362.4 |
Human leukocyte antigen A(HLA-A)ELISA Kit |
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GA-E0461HM-48T | GenAsia Biotech | 48T | EUR 346.8 |
Human leukocyte antigen A(HLA-A)ELISA Kit |
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GA-E0461HM-96T | GenAsia Biotech | 96T | EUR 559.2 |
Human HLA-A(Leukocyte Antigen A) ELISA Kit |
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EH3227 | FN Test | 96T | EUR 628.92 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml |
Human leukocyte antigen A(HLA-A)ELISA Kit |
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QY-E02401 | Qayee Biotechnology | 96T | EUR 433.2 |
Human leukocyte antigen A,HLA-A ELISA Kit |
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YLA1604HU-48T | Shanghai YL Biotech | 48T | EUR 435 |
Human leukocyte antigen A,HLA-A ELISA Kit |
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YLA1604HU-96T | Shanghai YL Biotech | 96T | EUR 562.5 |
Rabbit Leukocyte Antigen A (HLA-A) ELISA Kit |
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abx363025-96tests | Abbexa | 96 tests | EUR 990 |
Monkey Leukocyte Antigen A (HLA-A) ELISA Kit |
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abx359381-96tests | Abbexa | 96 tests | EUR 990 |
Chicken Leukocyte Antigen A (HLA-A) ELISA Kit |
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abx356025-96tests | Abbexa | 96 tests | EUR 990 |