Berberine Inhibits the gene Expression and Production

lumicyte

Berberine Inhibits the gene Expression and Production of Proinflammatory Cytokines by Mononuclear cells in Rheumatoid Arthritis and Healthy Individuals

  •  Objective: Rheumatoid arthritis (RA) is the most prevalent autoimmune arthritis. Berberine is an alkaloid isolated from Berberis vulgaris and its anti-inflammatory effect has been identified.
  • Method: Twenty newly diagnosed RA patients and 20 healthy controls participated. Peripheral mononuclear cells were prepared and stimulated with bacterial lipopolysachharide (LPS,1 µg/ml), exposed to different concentrations of berberine (10 and 50µM) and dexamethasone (10-7 M) as a reference. Toxicity of compounds was evaluated by WST-1 assay. Expression of TNF-α and IL-1β were determined by quantitative real-time PCR. Protein level of secreted TNF-α and IL1β were measured by using ELISA.
  • Result: Berberine did not have any toxic effect on cells, whereas Lipopolysachharide (LPS) stimulation caused a noticeable rise in TNF-α and IL-1β production. Berberine markedly downregulated the expression of both TNF-α and IL1β and inhibits TNF-α and IL-1β secretion from LPS-stimulated PBMCs.
  • Discussion: This study provided molecular basis for anti-inflammatory effect of berberine on human mononuclear cells through the suppression of TNF-a and IL-1secretion. Our findings highlighted the significant inhibitory effect of berberine on proinflammatory responses of mononuclear cells from rheumatoid arthritis individuals, which may be responsible for antiinflammatory property of Barberry. We observed that berberine at high concentration exhibited anti-inflammatory effect in PBMCs of both healthy and patient groups by suppression of TNF-a and IL-1cytokines at both mRNA and protein levels.
  • Conclusions: Berberine may inhibit the gene expression and production of pro-inflammatory cytokines by mononuclear cells in rheumatoid arthritis and healthy individuals without affecting cells viability. Future studies with larger sample size is needed to prove the idea.

Parainfluenza Type 3 Antigen

MBS318453-5x1mL 5x1mL
EUR 2425

Canine Parainfluenza Virus Antigen

NAT41593-100 0.1
EUR 391.66
Description: Canine Parainfluenza virus antigen, produced in MDCK cells.

Parainfluenza Virus Type 2 Antigen

PR-BA1262-L 1mg
EUR 1100.4
Description: native, Vero cell culture

Parainfluenza Virus Type 2 Antigen

PR-BA1262-S 250µg
EUR 366.3
Description: native, Vero cell culture

Parainfluenza Virus Type 2 Antigen

BA1262VS 1mg
EUR 917

Parainfluenza Type-1 Virus Antigen

VAC-0319 0.5ml
EUR 1598.4
Description: Protein

Parainfluenza Type-3 Virus Antigen

VAC-0320 0.5ml
EUR 1598.4
Description: Protein

Parainfluenza Virus Type 1 Antigen

PR-BA1261-L 1mg
EUR 1100.4
Description: native, MDCK cell culture

Parainfluenza Virus Type 1 Antigen

PR-BA1261-S 250µg
EUR 366.3
Description: native, MDCK cell culture

Parainfluenza Virus Type 3 Antigen

PR-BA1263-L 1mg
EUR 1100.4
Description: native, Vero cell culture

Parainfluenza Virus Type 3 Antigen

PR-BA1263-S 250µg
EUR 366.3
Description: native, Vero cell culture

Parainfluenza Virus Type 1 Antigen

BA1261VS 1mg
EUR 917

Parainfluenza Virus Type 3 Antigen

BA1263VS 1mg
EUR 485

OPMA04417-1ML - Parainfluenza Type 2 Antigen Protein

OPMA04417-1ML 1ml
EUR 559

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (HRP)

MBS6262618-01mL 0.1mL
EUR 680

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (HRP)

MBS6262618-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (PE)

MBS6263129-01mL 0.1mL
EUR 680

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (PE)

MBS6263129-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (AP)

MBS6260578-01mL 0.1mL
EUR 680

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (AP)

MBS6260578-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (APC)

MBS6261089-01mL 0.1mL
EUR 680

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (APC)

MBS6261089-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (FITC)

MBS6262108-01mL 0.1mL
EUR 680

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (FITC)

MBS6262108-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Virus type 2 (PIV-2) Antigen, Grade 2

MBS568584-1mL 1mL
EUR 690

Parainfluenza Virus type 2 (PIV-2) Antigen, Grade 2

MBS568584-5x1mL 5x1mL
EUR 2830

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (Biotin)

MBS6261599-01mL 0.1mL
EUR 680

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (Biotin)

MBS6261599-5x01mL 5x0.1mL
EUR 2920

OPMA04406-1ML - Parainfluenza Type 3 Antigen Protein

OPMA04406-1ML 1ml
EUR 559

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (MaxLight 490)

MBS6264151-01mL 0.1mL
EUR 680

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (MaxLight 490)

MBS6264151-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (MaxLight 550)

MBS6264662-01mL 0.1mL
EUR 680

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (MaxLight 550)

MBS6264662-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (MaxLight 650)

MBS6265173-01mL 0.1mL
EUR 680

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (MaxLight 650)

MBS6265173-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (MaxLight 750)

MBS6265684-01mL 0.1mL
EUR 680

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (MaxLight 750)

MBS6265684-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (MaxLight 405)

MBS6263640-01mL 0.1mL
EUR 680

Parainfluenza Type 2 (Parainfluenza Virus Type 2, Parainfluenza 2) (MaxLight 405)

MBS6263640-5x01mL 5x0.1mL
EUR 2920

Human Parainfluenza Virus Type 1 Lysate

NAT41619-100 0.1
EUR 512.85
Description: Parainfluenza Virus is an enveloped, negative-sense single-stranded RNA virus with a diameter of approximately 150 to 250 nm.

Human Parainfluenza Virus Type 3 Lysate

NAT41621-100 0.1
EUR 512.85
Description: Parainfluenza Virus is an enveloped, negative-sense single-stranded RNA virus with a diameter of approximately 150 to 250 nm.

Human Parainfluenza Virus Type 3 Lysate

NAT41621-500 0.5
EUR 2181.53
Description: Parainfluenza Virus is an enveloped, negative-sense single-stranded RNA virus with a diameter of approximately 150 to 250 nm.

Human Parainfluenza Virus Type 4A Lysate

NAT41622-100 0.1
EUR 512.85
Description: Parainfluenza Virus is an enveloped, negative-sense single-stranded RNA virus with a diameter of approximately 150 to 250 nm.

Human Parainfluenza Virus Type 4A Lysate

NAT41622-500 0.5
EUR 2181.53
Description: Parainfluenza Virus is an enveloped, negative-sense single-stranded RNA virus with a diameter of approximately 150 to 250 nm.

Parainfluenza Virus type 3 (PIV-3) Antigen, Grade 2

MBS568731-1mL 1mL
EUR 690

Parainfluenza Virus type 3 (PIV-3) Antigen, Grade 2

MBS568731-5x1mL 5x1mL
EUR 2830

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (AP)

MBS6450398-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (AP)

MBS6450398-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (APC)

MBS6450399-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (APC)

MBS6450399-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (HRP)

MBS6450402-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (HRP)

MBS6450402-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (PE)

MBS6450408-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (PE)

MBS6450408-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (HRP)

MBS6262617-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (HRP)

MBS6262617-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (HRP)

MBS6262619-01mL 0.1mL
EUR 915

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (HRP)

MBS6262619-5x01mL 5x0.1mL
EUR 3955

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (PE)

MBS6263128-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (PE)

MBS6263128-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (PE)

MBS6263130-01mL 0.1mL
EUR 915

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (PE)

MBS6263130-5x01mL 5x0.1mL
EUR 3955

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (AP)

MBS6260577-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (AP)

MBS6260577-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (AP)

MBS6260579-01mL 0.1mL
EUR 915

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (AP)

MBS6260579-5x01mL 5x0.1mL
EUR 3955

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (APC)

MBS6261088-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (APC)

MBS6261088-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (APC)

MBS6261090-01mL 0.1mL
EUR 915

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (APC)

MBS6261090-5x01mL 5x0.1mL
EUR 3955

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (FITC)

MBS6450401-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (FITC)

MBS6450401-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (FITC)

MBS6262107-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (FITC)

MBS6262107-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (FITC)

MBS6262109-01mL 0.1mL
EUR 915

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (FITC)

MBS6262109-5x01mL 5x0.1mL
EUR 3955

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (Biotin)

MBS6450400-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (Biotin)

MBS6450400-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (Biotin)

MBS6261598-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (Biotin)

MBS6261598-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (Biotin)

MBS6261600-01mL 0.1mL
EUR 915

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (Biotin)

MBS6261600-5x01mL 5x0.1mL
EUR 3955

OPEF01532-1ML - Parainfluenza Virus type 2 (PIV-2) Grade 2 Antigen

OPEF01532-1ML 1ml
EUR 635

Parainfluenza Type-2

iha-029 10µg
EUR 60
Description: Parainfluenza Virus Type-2

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (MaxLight 405)

MBS6450403-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (MaxLight 405)

MBS6450403-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (MaxLight 490)

MBS6450404-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (MaxLight 490)

MBS6450404-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (MaxLight 550)

MBS6450405-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (MaxLight 550)

MBS6450405-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (MaxLight 650)

MBS6450406-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (MaxLight 650)

MBS6450406-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (MaxLight 750)

MBS6450407-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (MaxLight 750)

MBS6450407-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (MaxLight 490)

MBS6264150-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (MaxLight 490)

MBS6264150-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (MaxLight 490)

MBS6264152-01mL 0.1mL
EUR 915

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (MaxLight 490)

MBS6264152-5x01mL 5x0.1mL
EUR 3955

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (MaxLight 550)

MBS6264661-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (MaxLight 550)

MBS6264661-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (MaxLight 550)

MBS6264663-01mL 0.1mL
EUR 915

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (MaxLight 550)

MBS6264663-5x01mL 5x0.1mL
EUR 3955

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (MaxLight 650)

MBS6265172-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (MaxLight 650)

MBS6265172-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (MaxLight 650)

MBS6265174-01mL 0.1mL
EUR 915

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (MaxLight 650)

MBS6265174-5x01mL 5x0.1mL
EUR 3955

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (MaxLight 750)

MBS6265683-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (MaxLight 750)

MBS6265683-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (MaxLight 750)

MBS6265685-01mL 0.1mL
EUR 915

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (MaxLight 750)

MBS6265685-5x01mL 5x0.1mL
EUR 3955

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (MaxLight 405)

MBS6263639-01mL 0.1mL
EUR 680

Parainfluenza Type 1 (Parainfluenza Virus Type 1, Parainfluenza 1) (MaxLight 405)

MBS6263639-5x01mL 5x0.1mL
EUR 2920

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (MaxLight 405)

MBS6263641-01mL 0.1mL
EUR 915

Parainfluenza Type 3 (Parainfluenza Virus Type 3, Parainfluenza 3) (MaxLight 405)

MBS6263641-5x01mL 5x0.1mL
EUR 3955

Parainfluenza Type 2 Antibody

abx022124-1mg 1 mg
EUR 1387.2

Parainfluenza Type 2 Antibody

abx022129-1mg 1 mg
EUR 777.6

Parainfluenza type 2 antibody

10-P53A 1 mg
EUR 435
Description: Mouse monoclonal Parainfluenza type 2 antibody

Parainfluenza type 2 antibody

10-P53B 1 mg
EUR 95
Description: Mouse monoclonal Parainfluenza type 2 antibody

Parainfluenza type 2 antibody

10C-CR3015M1 100 ug
EUR 166
Description: Mouse monoclonal Parainfluenza type 2 antibody

Brain Network Connectivity and Association with Catechol-O-Methyltransferase Gene Polymorphism in Korean Attention-Deficit Hyperactivity Disorder Children

Objective: We sought to determine if the links between and within the default mode network (DMN) and dorsal attention network (DAT) exhibited different conditions according to catechol-O-methyltransferase (COMT) gene polymorphism in relationship to attention-deficit hyperactivity disorder (ADHD) symptoms.

Methods: Fifty-seven children with ADHD and 48 healthy controls (HCs) were administered an intelligence test, the Children’s Depression Inventory, the Korean ADHD rating scale, and continuous performance test. Resting-state brain functional MRI scans were obtained, and COMT genotyping was performed to distinguish valine carriers and methionine homozygotes.

Results: Compared to controls, children with ADHD showed increased ADHD scale scores, increased visual commission errors, and increased functional connectivity (FC) within the DMN and DAT. Compared to all children with ADHD, children with the methionine homozygote and those who were valine carriers showed increased FC within the DMN and DAT and decreased FC between the DMN and DAT. FC within the DMN was also increased in HC valine carriers compared to HC children with the methionine homozygote, and in children with ADHD who were valine carriers compared to HC valine carriers.

Conclusion: We observed increased brain connectivity within the DMN and DAT and altered brain connectivity within and between the DMN and DAT associated with COMT polymorphism in children with ADHD.

Ovarian cancer predisposition beyond BRCA1 and BRCA2 genes

 Several genes associated with hereditary ovarian cancer have been discovered as a result of the work done with next generation sequencing. It is estimated that approximately 23% of ovarian carcinomas have a hereditary predisposition. The most common hereditary condition is represented by germline mutations in BRCA1 or BRCA2 genes that account for 20-25% of high grade serous ovarian cancer.

A number of other hereditary ovarian cancers are associated with different genes, with a crucial role in the DNA damage response pathway, such as the mismatch repair genes in Lynch syndrome, TP53 in Li-Fraumeni syndrome, STK11 in Peutz-Jeghers syndrome, CHEK2, RAD51, BRIP1, and PALB2. The goal of this manuscript is to summarize the published data regarding the molecular pathways involved in the pathogenesis of non-BRCA related hereditary ovarian cancer and to provide a tool that might be useful in discussing risk assessment, genetic testing, prevention strategies, as well as clinical and therapeutic implications for patients with ovarian cancer.

Transcriptome analysis of duck embryo fibroblasts for the dynamic response to duck tembusu virus infection and dual regulation of apoptosis genes

Duck Tembusu virus (DTMUV) is an emerging pathogenic flavivirus that has caused enormous economic losses in Southeast Asia. However, the pathogenic mechanism and host’s responses after DTMUV infection remain poorly understood. During this study, total mRNA sequencing (RNA-Seq) analysis was used to detect the global gene expression in DEFs at various time points after DTMUV infection.

We identified 326 genes altered significantly at all time points, and these genes were dynamically enriched in multifarious biological processes, including apoptosis, innate immune response, DNA replication, cell cycle arrest and DNA repair. Next, the results showed that apoptosis was induced and the proportion of apoptosis increased with time, and pro-apoptotic molecules caspases were activated.

The RNA-seq data analysis further revealed that most pro-apoptosis and anti-apoptosis genes were early continually responsive, and the genes involved in both intrinsic and extrinsic apoptotic pathways were initiated. Further, the considerably enriched immune-relevant pathways were involved in apoptosis process, and protein-protein interactions (PPIs) analysis showed that IL6, STAT1, TNFAIP3, CFLAR and PTGS2 may be key regulators of DEFs apoptosis. In conclusion, this study not only contributes to understanding the underlying mechanism of DEFs infection with DTMUV, but also provides new insights into targets screening for antiviral therapy.

Ro/SS-A Antigen (Ro-60/SS-A)

MBS651599-5x1000Units 5x1000Units
EUR 5710

SS-A (Ro) Antigen

GWB-977C72 1000 TESTS Ask for price

SS-A (Ro) Antigen

GWB-E89B9A 0.2 mg Ask for price

Ro/SS-A Antigen

MBS611481-2mL 2mL
EUR 445

Ro/SS-A Antigen

MBS611481-5x2mL 5x2mL
EUR 1850

SS-A (Ro) Antigen

MBS318013-1000Units 1000Units
EUR 1390

SS-A (Ro) Antigen

MBS318013-5x1000Units 5x1000Units
EUR 6020

SS-A (Ro) Antigen

MBS318128-02mg 0.2mg
EUR 1420

SS-A (Ro) Antigen

MBS318128-5x02mg 5x0.2mg
EUR 6135

SS-A / Ro Antigen Antibody

abx022699-2ml 2 ml
EUR 594

SS-A / Ro Antigen Antibody

abx022699-400l 400 µl Ask for price

SS-A / Ro Antigen Antibody

abx022699-80l 80 µl
EUR 575

OPMA04224-200UG - SS-A (Ro) Antigen Protein

OPMA04224-200UG 0.2MG
EUR 1499

SS-A Antigen

E61A00301 1mg
EUR 750

SS-A Antigen

MBS569398-1mg 1mg
EUR 1705

SS-A Antigen

MBS569398-5x1mg 5x1mg
EUR 7395

SS-A Antigen

MBS8506877-1mg 1mg
EUR 830

SS-A Antigen

MBS8506877-5x1mg 5x1mg
EUR 3595

Ro/SS-A Antigen (SSA1, Sjogren Syndrome Antigen A1, 52kD Ribonucleoprotein Autoantigen SS-A/Ro, RO52, RNF81, Tripartite Motif Protein 21, TRIM21)

MBS651596-1000Units 1000Units
EUR 1730

Ro/SS-A Antigen (SSA1, Sjogren Syndrome Antigen A1, 52kD Ribonucleoprotein Autoantigen SS-A/Ro, RO52, RNF81, Tripartite Motif Protein 21, TRIM21)

MBS651596-5x1000Units 5x1000Units
EUR 7555

Ro/SS-A Antigen (SSA1, Sjogren Syndrome Antigen A1, 52kD Ribonucleoprotein Autoantigen SS-A/Ro, RO52, RNF81, Tripartite Motif Protein 21, TRIM21)

MBS651597-02mg 0.2mg
EUR 1395

Ro/SS-A Antigen (SSA1, Sjogren Syndrome Antigen A1, 52kD Ribonucleoprotein Autoantigen SS-A/Ro, RO52, RNF81, Tripartite Motif Protein 21, TRIM21)

MBS651597-5x02mg 5x0.2mg
EUR 6060

Ro-60/SS-A Antigen (60kD), Recombinant, Human (SSA1, Sjogren Syndrome Antigen A1, 52kD Ribonucleoprotein Autoantigen SS-A/Ro, RO52, RNF81, Tripartite Motif Protein 21, TRIM21)

MBS635764-001mg 0.01mg
EUR 375

Ro-60/SS-A Antigen (60kD), Recombinant, Human (SSA1, Sjogren Syndrome Antigen A1, 52kD Ribonucleoprotein Autoantigen SS-A/Ro, RO52, RNF81, Tripartite Motif Protein 21, TRIM21)

MBS635764-005mg 0.05mg
EUR 525

Ro-60/SS-A Antigen (60kD), Recombinant, Human (SSA1, Sjogren Syndrome Antigen A1, 52kD Ribonucleoprotein Autoantigen SS-A/Ro, RO52, RNF81, Tripartite Motif Protein 21, TRIM21)

MBS635764-5x005mg 5x0.05mg
EUR 2210

Borrelia Afzelii Antigen

NAT41583-100 0.1
EUR 391.66
Description: Harvested bacteria are washed and detergent solubilized to produce a cytoplasmic extract enriched with lipoproteins and outer surface proteins (OSPs). The antigen is presented in phosphate buffered saline containing 1 % n-octyl-β-D-glucopyranoside.

Borrelia Afzelii Antigen

NAT41583-500 0.5
EUR 1176.24
Description: Harvested bacteria are washed and detergent solubilized to produce a cytoplasmic extract enriched with lipoproteins and outer surface proteins (OSPs). The antigen is presented in phosphate buffered saline containing 1 % n-octyl-β-D-glucopyranoside.

Borrelia Garinii Antigen

NAT41584-100 0.1
EUR 391.66
Description: Harvested bacteria are washed and detergent solubilized to produce a cytoplasmic extract enriched with lipoproteins and outer surface proteins (OSPs). The antigen is presented in phosphate buffered saline containing 1 % n-octyl-β-D-glucopyranoside.

Borrelia Garinii Antigen

NAT41584-500 0.5
EUR 1176.24
Description: Harvested bacteria are washed and detergent solubilized to produce a cytoplasmic extract enriched with lipoproteins and outer surface proteins (OSPs). The antigen is presented in phosphate buffered saline containing 1 % n-octyl-β-D-glucopyranoside.

Brucella Abortus Antigen

NAT41599-100 0.1
EUR 391.66
Description: Brucella abortus lysate, produced by fermentation.

Brucella Abortus Antigen

NAT41599-500 0.5
EUR 1176.24
Description: Brucella abortus lysate, produced by fermentation.

Candida Albicans Antigen

NAT41601-100 0.1
EUR 391.66
Description: Candida albicans is grown on solid medium, washed, disrupted and subjected to an extraction process. The antigen consists of cytoplasmic and cell wall components.

Candida Albicans Antigen

NAT41601-500 0.5
EUR 1176.24
Description: Candida albicans is grown on solid medium, washed, disrupted and subjected to an extraction process. The antigen consists of cytoplasmic and cell wall components.

Canine Parvovirus Antigen

NAT41594-100 0.1
EUR 391.66
Description: Canine Parvovirus, produced in CRFK cells.

Canine Coronavirus Antigen

NAT41590-100 0.1
EUR 391.66
Description: Canine Coronavirus produced in A-72 cells.

Feline Calicivirus Antigen

NAT41595-100 0.1
EUR 391.66
Description: Feline Calicivirus produced in FC 3TG cells.

Helicobacter Pylori Antigen

NAT41603-100 0.1
EUR 391.66
Description: Bacteria are cultured on solid medium, harvested, washed and solubilised. The antigen is partially purified by detergent extraction and centrifugation.

Helicobacter Pylori Antigen

NAT41603-500 0.5
EUR 1176.24
Description: Bacteria are cultured on solid medium, harvested, washed and solubilised. The antigen is partially purified by detergent extraction and centrifugation.

Campylobacter Jejuni Antigen

NAT41600-100 0.1
EUR 391.66
Description: Campylobacter jejuni is cultured on solid medium. This antigen is a partially purified detergent extract of the membrane fraction. The main component is an outer membrane protein, approximately 45 kDa in SDS-PAGE.

Campylobacter Jejuni Antigen

NAT41600-500 0.5
EUR 1176.24
Description: Campylobacter jejuni is cultured on solid medium. This antigen is a partially purified detergent extract of the membrane fraction. The main component is an outer membrane protein, approximately 45 kDa in SDS-PAGE.

Chlamydia Trachomatis Antigen

CT022-1000 1.0
EUR 378.9
Description: Chlamydia trachomatis antigens from clarified cell lysate.

Neisseria Gonorrhoeae Antigen

NG01-1000 1.0
EUR 378.9
Description: Homogenised lysate of pure bacteria.

Mycoplasma Pneumoniae Antigen

MP901-1000 1.0
EUR 1010.39
Description: Mycoplasma pneumoniae whole organisms that have been purified and detergent treated to enrich antigenic proteins and decrease background.

Mycoplasma Pneumoniae Antigen

MP901-200 0.2
EUR 270.46
Description: Mycoplasma pneumoniae whole organisms that have been purified and detergent treated to enrich antigenic proteins and decrease background.

Echovirus Antigen, Recombinant

REC31776-100 0.1
EUR 276.84
Description: Proprietary recombinant antigen expressed in E. coli and purified by chromatography. Individually pooled antigens shown to react with QC serum panel (multiple negative, borderline and positive sera) within defined reactivity range in Coxsackie-/Echovirus

Echovirus Antigen, Recombinant

REC31776-500 0.5
EUR 1043.56
Description: Proprietary recombinant antigen expressed in E. coli and purified by chromatography. Individually pooled antigens shown to react with QC serum panel (multiple negative, borderline and positive sera) within defined reactivity range in Coxsackie-/Echovirus

Trichomonas Vaginalis Antigen

TV01-1000 1.0
EUR 421
Description: Washed & lysed suspension of whole protozoa

Echinococcus Granulosus Antigen

NAT41602-100 0.1
EUR 391.66
Description: Echinococcus granulosus material is derived from bovine hydatid cyst as sterile filtered cyst fluid.

Echinococcus Granulosus Antigen

NAT41602-500 0.5
EUR 1176.24
Description: Echinococcus granulosus material is derived from bovine hydatid cyst as sterile filtered cyst fluid.

Enterovirus Antigen, Recombinant

REC31772-100 0.1
EUR 276.84
Description: Proprietary recombinant antigen expressed in E. coli and purified by chromatography. Individually pooled antigens shown to react with QC serum panel (multiple negative, borderline and positive sera) within defined reactivity range in Coxsackie-/Echovirus IgA, IgG and IgM ELISA.

Enterovirus Antigen, Recombinant

REC31772-500 0.5
EUR 1043.56
Description: Proprietary recombinant antigen expressed in E. coli and purified by chromatography. Individually pooled antigens shown to react with QC serum panel (multiple negative, borderline and positive sera) within defined reactivity range in Coxsackie-/Echovirus IgA, IgG and IgM ELISA.

Cytomegalovirus Purified Antigen

CMV-HP-100 0.1
EUR 318.94
Description: A concentrated source of human Cytomegalovirus particles purified by sucrose gradient ultracentrifugation.

Cytomegalovirus Purified Antigen

CMV-HP-1000 1.0
EUR 2096.06
Description: A concentrated source of human Cytomegalovirus particles purified by sucrose gradient ultracentrifugation.

Cytomegalovirus Purified Antigen

CMV-HP-500 0.5
EUR 1279.58
Description: A concentrated source of human Cytomegalovirus particles purified by sucrose gradient ultracentrifugation.

Astrovirus Antigen (Type 1)

AS02-1000 1.0
EUR 1654.65
Description: A concentrated source of Astrovirus particles and Astrovirus proteins from a lysate of host cells.

Astrovirus Antigen (Type 1)

AS02-200 0.2
EUR 442.69
Description: A concentrated source of Astrovirus particles and Astrovirus proteins from a lysate of host cells.

Yersinia pestis V antigen

REC32028-100 0.1
EUR 491.53
Description: Yersinia pestis V antigen (LcrV antigen, capsule protein fraction 1, type III secretion system needle tip protein). The protein is produced as an N-terminal GST fusion, with GST being cleaved by thrombin and is not present in the final product.

Yersinia pestis V antigen

REC32028-500 0.5
EUR 2421.37
Description: Yersinia pestis V antigen (LcrV antigen, capsule protein fraction 1, type III secretion system needle tip protein). The protein is produced as an N-terminal GST fusion, with GST being cleaved by thrombin and is not present in the final product.

Canine Herpes Virus Antigen

NAT41592-100 0.1
EUR 391.66
Description: Canine Herpes virus, produced in MDCK cells.

Canine Adenovirus 1 Antigen

NAT41587-100 0.1
EUR 391.66
Description: Canine Adenovirus Type 1, produced in A-72 cells.

Canine Adenovirus 2 Antigen

NAT41588-100 0.1
EUR 391.66
Description: Canine Adenovirus Type 2, produced in A-72 cells.

Canine Distemper Virus Antigen

NAT41591-100 0.1
EUR 391.66
Description: Canine Distemper virus, produced in SL-29 cells.

Canine Parainfluenza Virus Antigen

NAT41593-100 0.1
EUR 391.66
Description: Canine Parainfluenza virus antigen, produced in MDCK cells.

Feline Panleukopenia Virus Antigen

NAT41597-100 0.1
EUR 391.66
Description: Feline Panleukopenia Virus (FPLV; feline parvovirus) antigen, produced in CRFK cells.

Norovirus GII.4 VP1 Antigen

REC31620-100 0.1
EUR 302.36
Description: Recombinant Norovirus GII.4 VP1 antigen produced in 293 human cells.

Norovirus GII.4 VP1 Antigen

REC31620-1000 1.0
EUR 1830.71
Description: Recombinant Norovirus GII.4 VP1 antigen produced in 293 human cells.

Norovirus GII.4 VP1 Antigen

REC31620-500 0.5
EUR 1066.53
Description: Recombinant Norovirus GII.4 VP1 antigen produced in 293 human cells.

Cytomegalovirus Cell Lysate Antigen

CMV-CL-100 0.1
EUR 223.26
Description: A clarified cell lysate containing a mix of CMV antigens from all stages of the replication life cycle.

Cytomegalovirus Cell Lysate Antigen

CMV-CL-1000 1.0
EUR 1422.47
Description: A clarified cell lysate containing a mix of CMV antigens from all stages of the replication life cycle.

Feline Viral Rhinotracheitis Antigen

NAT41598-100 0.1
EUR 391.66
Description: Feline Viral Rhinotracheitis (FVR; feline herpes virus, FHV-1) antigen, produced in CRFK cells.

Herpes Simplex Virus 1 Antigen

HS105-1000 1.0
EUR 1178.79
Description: HSV-1 particles from a cell lysate are purified by sucrose gradient ultracentrifugation.

Herpes Simplex Virus 1 Antigen

HS105-200 0.2
EUR 294.7
Description: HSV-1 particles from a cell lysate are purified by sucrose gradient ultracentrifugation.

Herpes Simplex Virus 2 Antigen

HS205-1000 1.0
EUR 1178.79
Description: HSV-2 particles from a cell lysate are purified by sucrose gradient ultracentrifugation.

Herpes Simplex Virus 2 Antigen

HS205-200 0.2
EUR 294.7
Description: HSV-2 particles from a cell lysate are purified by sucrose gradient ultracentrifugation.

Ross River Virus Recombinant Antigen

REC31969-100 0.1
EUR 757.8
Description: Recombinant Ross River virus antigen expressed in HEK293 cells as virus-like particles and purified by sucrose density gradients and precipitation. Virus-like particles were then solubilized in PBS containing 0.2% SDS to prevent aggregation of particles. The preparation is not particulate. Antigens in the preparation include Envelope proteins 1 and 2 and Nucleoprotein.

Ross River Virus Recombinant Antigen

REC31969-500 0.5
EUR 2844.92
Description: Recombinant Ross River virus antigen expressed in HEK293 cells as virus-like particles and purified by sucrose density gradients and precipitation. Virus-like particles were then solubilized in PBS containing 0.2% SDS to prevent aggregation of particles. The preparation is not particulate. Antigens in the preparation include Envelope proteins 1 and 2 and Nucleoprotein.

Canine Adenovirus 1 and 2 Antigen

NAT41589-100 0.1
EUR 391.66
Description: A mixture of Canine Adenovirus Type 1 and Type 2, produced in A-72 cells.

Hepatitis B Virus E Antigen (HBeAg)

REC31677-100 0.1
EUR 456.72
Description: Recombinant Hepititis B Virus E Protein (HBeAg).

Hepatitis B Virus E Antigen (HBeAg)

REC31677-500 0.5
EUR 1941.06
Description: Recombinant Hepititis B Virus E Protein (HBeAg).

Hepatitis B Virus Core Antigen (HBcAg)

REC31689-100 0.1
EUR 456.72
Description: Recombinant Hepititis B Virus Core Protein (HBcAg).

Hepatitis B Virus Core Antigen (HBcAg)

REC31689-500 0.5
EUR 1370.16
Description: Recombinant Hepititis B Virus Core Protein (HBcAg).

Hepatitis C Virus Core Antigen (HCcAg)

REC31693-100 0.1
EUR 484.79
Description: Recombinant Hepatitis C Virus core protein is produced in E. coli and fused with a His-tag.

Hepatitis C Virus Core Antigen (HCcAg)

REC31693-500 0.5
EUR 1455.64
Description: Recombinant Hepatitis C Virus core protein is produced in E. coli and fused with a His-tag.

OPEF01636-1MG - Recombinant SS-A Antigen

OPEF01636-1MG 1mg
EUR 1683

Feline Infectious Peritonitis Virus Antigen

NAT41596-100 0.1
EUR 391.66
Description: Feline Infectious Peritonitis virus (FIPV; feline coronavirus) antigen, produced in CRFK cells.

Herpes Simplex Virus 1 Lysate Antigen

HS104-1000 1.0
EUR 270.46
Description: A high concentration of HSV-1 particles and proteins from a clarified cell lysate.

Herpes Simplex Virus 2 Lysate Antigen

HS204-1000 1.0
EUR 270.46
Description: A high concentration of HSV-2 particles and proteins from a clarified cell lysate.

Legionella pneumophila antigen (native extract)

NAT41580-100 0.1
EUR 391.66
Description: Inactivated Legionella pneumophila antigen from culture.

Streptococcus Pneumoniae Antigen, Native Extract

NAT41604-100 0.1
EUR 391.66
Description: Inactivated Streptococcus pneumoniae antigen from culture.

Leptospira Biflexa Antigen (Strain Patoc 1)

NAT41582-100 0.1
EUR 391.66
Description: Inactivated Leptospira biflexa antigen (Strain Patoc 1) from broth culture.

Leptospira Biflexa Antigen (Strain Patoc 1)

NAT41582-500 0.5
EUR 1176.24
Description: Inactivated Leptospira biflexa antigen (Strain Patoc 1) from broth culture.

SS-B Antigen

E61A00401 1mg
EUR 750

SS-B Antigen

MBS569399-1mg 1mg
EUR 1705

SS-B Antigen

MBS569399-5x1mg 5x1mg
EUR 7395

SS-B Antigen

MBS8506643-1mg 1mg
EUR 830

SS-B Antigen

MBS8506643-5x1mg 5x1mg
EUR 3595

TROVE2 (RO60, SSA2, 60kD SS-A/Ro Ribonucleoprotein, Ro 60kD Autoantigen, Sjoegren Syndrome Antigen A2, Sjoegren Syndrome Type A Antigen, TROVE Domain Family Member 2) (AP)

MBS6134337-01mL 0.1(mL
EUR 875

TROVE2 (RO60, SSA2, 60kD SS-A/Ro Ribonucleoprotein, Ro 60kD Autoantigen, Sjoegren Syndrome Antigen A2, Sjoegren Syndrome Type A Antigen, TROVE Domain Family Member 2) (AP)

MBS6134337-5x01mL 5x0.1mL
EUR 3800

TROVE2 (RO60, SSA2, 60kD SS-A/Ro Ribonucleoprotein, Ro 60kD Autoantigen, Sjoegren Syndrome Antigen A2, Sjoegren Syndrome Type A Antigen, TROVE Domain Family Member 2) (Biotin)

MBS6144943-01mL 0.1(mL
EUR 875

TROVE2 (RO60, SSA2, 60kD SS-A/Ro Ribonucleoprotein, Ro 60kD Autoantigen, Sjoegren Syndrome Antigen A2, Sjoegren Syndrome Type A Antigen, TROVE Domain Family Member 2) (Biotin)

MBS6144943-5x01mL 5x0.1mL
EUR 3800

TROVE2 (RO60, SSA2, 60kD SS-A/Ro Ribonucleoprotein, Ro 60kD Autoantigen, Sjoegren Syndrome Antigen A2, Sjoegren Syndrome Type A Antigen, TROVE Domain Family Member 2) APC

MBS6139640-01mL 0.1(mL
EUR 875

TROVE2 (RO60, SSA2, 60kD SS-A/Ro Ribonucleoprotein, Ro 60kD Autoantigen, Sjoegren Syndrome Antigen A2, Sjoegren Syndrome Type A Antigen, TROVE Domain Family Member 2) APC

MBS6139640-5x01mL 5x0.1mL
EUR 3800

TROVE2 (RO60, SSA2, 60kD SS-A/Ro Ribonucleoprotein, Ro 60kD Autoantigen, Sjoegren Syndrome Antigen A2, Sjoegren Syndrome Type A Antigen, TROVE Domain Family Member 2) (AP)

MBS6397325-01mL 0.1mL
EUR 920

TROVE2 (RO60, SSA2, 60kD SS-A/Ro Ribonucleoprotein, Ro 60kD Autoantigen, Sjoegren Syndrome Antigen A2, Sjoegren Syndrome Type A Antigen, TROVE Domain Family Member 2) (AP)

MBS6397325-5x01mL 5x0.1mL
EUR 3990

TROVE2 (RO60, SSA2, 60kD SS-A/Ro Ribonucleoprotein, Ro 60kD Autoantigen, Sjoegren Syndrome Antigen A2, Sjoegren Syndrome Type A Antigen, TROVE Domain Family Member 2) APC

MBS6397326-01mL 0.1mL
EUR 920

TROVE2 (RO60, SSA2, 60kD SS-A/Ro Ribonucleoprotein, Ro 60kD Autoantigen, Sjoegren Syndrome Antigen A2, Sjoegren Syndrome Type A Antigen, TROVE Domain Family Member 2) APC

MBS6397326-5x01mL 5x0.1mL
EUR 3990

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