Rather than Genes, Unite the Highly Divergent Bilateria

Conserved Patterns in Developmental Processes and Phases, Rather than Genes, Unite the Highly Divergent Bilateria

Bilateria are the predominant clade of animals on Earth. Despite having evolved a wide variety of body plans and developmental modes, they are characterized by common morphological traits. By default, researchers have tried to link clade-specific genes to these traits, thus distinguishing bilaterians from non-bilaterians, by their gene content. Here we argue that it is rather biological processes that unite Bilateria and set them apart from their non-bilaterian sisters, with a less complex body morphology.

To test this hypothesis, we compared proteomes of bilaterian and non-bilaterian species in an elaborate computational pipeline, aiming to search for a set of bilaterian-specific genes. Despite the limited confidence in their bilaterian specificity, we nevertheless detected Bilateria-specific functional and developmental patterns in the sub-set of genes conserved in distantly related Bilateria.

Using a novel multi-species GO-enrichment method, we determined the functional repertoire of genes that are widely conserved among Bilateria. Analyzing expression profiles in three very distantly related model species-D. melanogasterD. rerio and C. elegans-we find characteristic peaks at comparable stages of development and a delayed onset of expression in embryos. In particular, the expression of the conserved genes appears to peak at the phylotypic stage of different bilaterian phyla.

In summary, our study illustrate how development connects distantly related Bilateria after millions of years of divergence, pointing to processes potentially separating them from non-bilaterians. We argue that evolutionary biologists should return from a purely gene-centric view of evolution and place more focus on analyzing and defining conserved developmental processes and periods.

FOXD3 Antibody

34110-50ul 50ul
EUR 224.4

FOXD3 Antibody

E036865 100μg/100μl
EUR 255
Description: Available in various conjugation types.

FOXD3 Antibody

E034110 100μg/100μl
EUR 255
Description: Available in various conjugation types.

FOXD3 Antibody

E19-3471 100μg/100μl
EUR 225
Description: Available in various conjugation types.

FOXD3 Antibody

E10-30128 100μg/100μl
EUR 225
Description: Available in various conjugation types.

FOXD3 Antibody

E10-30141 100μg/100μl
EUR 225
Description: Available in various conjugation types.

FOXD3 Antibody

E11-11862C 100μg
EUR 225
Description: Available in various conjugation types.

FOXD3 Antibody

E38PA3942 100ul
EUR 225
Description: Available in various conjugation types.

FOXD3 Antibody

E81107-4 100ul
EUR 225
Description: Available in various conjugation types.

FOXD3 Antibody

E92926 100μg
EUR 255
Description: Available in various conjugation types.

FOXD3 Antibody

GWB-1B7C02 0.05 mg Ask for price

FOXD3 Antibody

DF3471 200ul
EUR 420

FOXD3 Antibody

DF3471-100ul 100ul
EUR 280

FOXD3 Antibody

DF3471-200ul 200ul
EUR 350

FOXD3 Antibody

1-CSB-PA002566
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  • 100ug
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Description: A polyclonal antibody against FOXD3. Recognizes FOXD3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

FOXD3 Antibody

36865 100ul
EUR 319

FOXD3 Antibody

36865-100ul 100ul
EUR 302.4

FOXD3 antibody

70R-32198 100 ug
EUR 294
Description: Rabbit polyclonal FOXD3 antibody

FOXD3 Antibody

BF0061 200ul
EUR 540

FOXD3 Antibody

BF0061-100ul 100ul
EUR 350

FOXD3 Antibody

BF0061-200ul 200ul
EUR 450

FOXD3 Antibody

BF0061-50ul 50ul
EUR 250

FOXD3 Antibody

ABD3471 100 ug
EUR 525.6

FOXD3 Antibody

CAC11225-100ug 100ug
EUR 314

FOXD3 Antibody

CAC11225-50ug 50ug
EUR 199.2

FOXD3 Antibody

1-CSB-PA238725
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  • 100ul
  • 50ul
Description: A polyclonal antibody against FOXD3. Recognizes FOXD3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;ELISA:1:1000-1:5000, WB:1:500-1:2000

FOXD3 Antibody

CSB-PA298737- each
EUR 402
Description: A polyclonal antibody against FOXD3. Recognizes FOXD3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100

FOXD3 Antibody

CSB-PA298737-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against FOXD3. Recognizes FOXD3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100

FOXD3 Antibody

1-CSB-PA173245
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  • 100ul
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Description: A polyclonal antibody against FOXD3. Recognizes FOXD3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;ELISA:1:1000-1:5000, WB:1:500-1:2000

FOXD3 Antibody

1-CSB-PA890729LA01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against FOXD3. Recognizes FOXD3 from Human, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

FOXD3 Antibody

8C11862 50ug
EUR 368
Description: FOXD3 Antibody

Polyclonal FOXD3 Antibody

APR11944G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FOXD3 . This antibody is tested and proven to work in the following applications:

FoxD3 Polyclonal Antibody

E20-71743 100ug
EUR 225
Description: Available in various conjugation types.

FOXD3 Conjugated Antibody

C34110 100ul
EUR 476.4

FOXD3 Conjugated Antibody

C36865 100ul
EUR 476.4

FoxD3 Polyclonal Antibody

ABP51363-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of FoxD3 from Human, Mouse. This FoxD3 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human FoxD3 at AA range: 180-260

FoxD3 Polyclonal Antibody

ABP51363-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of FoxD3 from Human, Mouse. This FoxD3 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human FoxD3 at AA range: 180-260

FoxD3 Polyclonal Antibody

ABP51363-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of FoxD3 from Human, Mouse. This FoxD3 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human FoxD3 at AA range: 180-260

FoxD3 Polyclonal Antibody

E44H04724 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

FOXD3 Polyclonal Antibody

E-AB-15644-120uL 120uL
EUR 240
Description: Unconjugated

FOXD3 Polyclonal Antibody

E-AB-15644-200uL 200uL
EUR 399
Description: Unconjugated

FOXD3 Polyclonal Antibody

E-AB-15644-20uL 20uL
EUR 73
Description: Unconjugated

FOXD3 Polyclonal Antibody

E-AB-15644-60uL 60uL
EUR 143
Description: Unconjugated

FOXD3 Polyclonal Antibody

E-AB-12423-120uL 120uL
EUR 240
Description: Unconjugated

FOXD3 Polyclonal Antibody

E-AB-12423-200uL 200uL
EUR 399
Description: Unconjugated

FOXD3 Polyclonal Antibody

E-AB-12423-20uL 20uL
EUR 73
Description: Unconjugated

FOXD3 Polyclonal Antibody

E-AB-12423-60uL 60uL
EUR 143
Description: Unconjugated

FOXD3 Antibody, HRP conjugated

1-CSB-PA890729LB01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against FOXD3. Recognizes FOXD3 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

FOXD3 Antibody, FITC conjugated

1-CSB-PA890729LC01HU
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  • 100ug
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Description: A polyclonal antibody against FOXD3. Recognizes FOXD3 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

FOXD3 Antibody, Biotin conjugated

1-CSB-PA890729LD01HU
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  • 100ug
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Description: A polyclonal antibody against FOXD3. Recognizes FOXD3 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

OAAJ04351-100UL - FOXD3 Antibody

OAAJ04351-100UL 100uL
EUR 319

OAEC04703-100UL - FOXD3 Antibody

OAEC04703-100UL 100ug/100ul
EUR 249

OAEC04715-100UL - FOXD3 Antibody

OAEC04715-100UL 100ug/100ul
EUR 249

OAAB19485-100UL - FOXD3 Antibody

OAAB19485-100UL 100ul
EUR 389

OAAD00386-100UL - FOXD3 Antibody

OAAD00386-100UL 0.1ml
EUR 369

OAAF02735-100UG - FOXD3 Antibody

OAAF02735-100UG 100ug
EUR 329

Forkhead Box D3 (FOXD3) Antibody

20-abx326019
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  • 100 ug
  • 50 ug

Forkhead Box D3 (FOXD3) Antibody

abx331588-100ul 100 ul
EUR 510

Forkhead Box D3 (FOXD3) Antibody

20-abx338846
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Forkhead Box D3 (FOXD3) Antibody

20-abx212373
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  • 100 ul
  • 50 ul

Forkhead Box D3 (FOXD3) Antibody

20-abx212374
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  • 100 ul
  • 50 ul

Forkhead Box D3 (FOXD3) Antibody

20-abx121480
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  • 100 ul
  • 200 ul
  • 30 ul

Forkhead Box D3 (FOXD3) Antibody

20-abx007250
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  • 100 ul
  • 200 ul
  • 50 ul

Forkhead Box D3 (FOXD3) Antibody

abx010794-100ul 100 ul
EUR 493.2

Forkhead Box D3 (FOXD3) Antibody

20-abx013843
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  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Forkhead Box D3 (FOXD3) Antibody

abx015864-100ul 100 ul
EUR 493.2

Forkhead Box D3 (FOXD3) Antibody

abx019086-100ug 100 ug
EUR 410.4

Forkhead Box D3 (FOXD3) Antibody

abx013843-100l 100 µl
EUR 43.75

Forkhead Box D3 (FOXD3) Antibody

abx007250-100g 100 µg
EUR 400

Forkhead Box D3 (FOXD3) Antibody

abx007250-10g 10 µg
EUR 275

Forkhead Box D3 (FOXD3) Antibody

abx007250-200g 200 µg
EUR 600

Forkhead Box D3 (FOXD3) Antibody

abx010794-100g 100 µg Ask for price

Forkhead Box D3 (FOXD3) Antibody

abx010794-10g 10 µg
EUR 362.5

Forkhead Box D3 (FOXD3) Antibody

abx010794-200g 200 µg Ask for price

Forkhead Box D3 (FOXD3) Antibody

abx015864-1mg 1 mg
EUR 362.5

Forkhead Box D3 (FOXD3) Antibody

abx019086-1mg 1 mg
EUR 300

Forkhead Box D3 (FOXD3) Antibody

abx212373-100l 100 µl
EUR 350

Forkhead Box D3 (FOXD3) Antibody

abx212373-50l 50 µl
EUR 250

Forkhead Box D3 (FOXD3) Antibody

abx212374-100l 100 µl
EUR 350

Forkhead Box D3 (FOXD3) Antibody

abx212374-50l 50 µl
EUR 250

Forkhead Box D3 (FOXD3) Antibody

abx326019-100g 100 µg
EUR 250

Forkhead Box D3 (FOXD3) Antibody

abx326019-50g 50 µg
EUR 187.5

Forkhead Box D3 (FOXD3) Antibody

abx338846-100g 100 µg
EUR 362.5

Forkhead Box D3 (FOXD3) Antibody

abx338846-20g 20 µg
EUR 162.5

Forkhead Box D3 (FOXD3) Antibody

abx338846-50g 50 µg
EUR 250

FoxD3 Rabbit Polyclonal Antibody

ES2362-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against FoxD3 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

FoxD3 Rabbit Polyclonal Antibody

ES2362-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against FoxD3 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

FOXD3 rabbit polyclonal antibody

RA25044-100 100 µg Ask for price

FOXD3 Rabbit Polyclonal Antibody

E10G03932 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

FOXD3 Rabbit Polyclonal Antibody

E10G10861 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Monoclonal FOXD3 Antibody, Clone: 5G9

APR16020G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human FOXD3. The antibodies are raised in Mouse and are from clone 5G9. This antibody is applicable in WB and IHC, E

Polyclonal FOXD3 Antibody (aa211-260)

APR11945G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FOXD3 (aa211-260). This antibody is tested and proven to work in the following applications:

Forkhead Box D3 (FOXD3) Antibody (HRP)

20-abx335712
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Forkhead Box D3 (FOXD3) Antibody (HRP)

abx335712-100g 100 µg
EUR 362.5

Forkhead Box D3 (FOXD3) Antibody (HRP)

abx335712-20g 20 µg
EUR 162.5

Forkhead Box D3 (FOXD3) Antibody (HRP)

abx335712-50g 50 µg
EUR 250

Forkhead Box D3 (FOXD3) Antibody (FITC)

20-abx335713
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Forkhead Box D3 (FOXD3) Antibody (FITC)

abx335713-100g 100 µg
EUR 362.5

Forkhead Box D3 (FOXD3) Antibody (FITC)

abx335713-20g 20 µg
EUR 162.5

Forkhead Box D3 (FOXD3) Antibody (FITC)

abx335713-50g 50 µg
EUR 250

Forkhead Box D3 (FOXD3) Antibody (Biotin)

20-abx335714
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Forkhead Box D3 (FOXD3) Antibody (Biotin)

abx335714-100g 100 µg
EUR 362.5

Forkhead Box D3 (FOXD3) Antibody (Biotin)

abx335714-20g 20 µg
EUR 162.5

Forkhead Box D3 (FOXD3) Antibody (Biotin)

abx335714-50g 50 µg
EUR 250

Mouse Monoclonal Antibody to FOXD3

MAB-606030128 0.1ml
EUR 280

Mouse Monoclonal Antibody to FOXD3

sAP-0480 50ug
EUR 270

Mouse Monoclonal Antibody to FOXD3

sAP-0493 50ug
EUR 270

FOXD3 rabbit polyclonal antibody, Serum

AP54941SU-N 200 µl Ask for price

ARP32561_P050-25UL - FOXD3 Antibody - middle region

ARP32561_P050-25UL 25ul
EUR 99

OASG02781-100UL - FOXD3 Antibody - middle region

OASG02781-100UL 100ul
EUR 239

ARP32561_P050 - FOXD3 antibody - middle region (ARP32561_P050)

ARP32561_P050 100ul
EUR 389

FOXD3 rabbit polyclonal antibody, Aff - Purified

AP06761PU-N 100 µg Ask for price

Foxd3/ Rat Foxd3 ELISA Kit

ELI-26723r 96 Tests
EUR 1063.2

FOXD3 mouse monoclonal antibody, clone 5G9, Ascites

AM06541SU-N 100 µl Ask for price

FOXD3 mouse monoclonal antibody, clone 5G9, Ascites

AM06554SU-N 100 µl Ask for price

FOXD3

E8R1107-4 100ul
EUR 275
Description: Available in various conjugation types.

FOXD3

RA25044 100 ug
EUR 631.2

FOXD3 (untagged)-Human forkhead box D3 (FOXD3)

SC303938 10 µg Ask for price

FOXD3 siRNA

20-abx917099
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  • 15 nmol
  • 30 nmol

FOXD3 siRNA

20-abx917100
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  • 15 nmol
  • 30 nmol

FOXD3 (GFP-tagged) - Human forkhead box D3 (FOXD3)

RG214719 10 µg Ask for price

Foxd3 (untagged) - Mouse forkhead box D3 (Foxd3), (10ug)

MC216257 10 µg Ask for price

Foxd3 (GFP-tagged) - Mouse forkhead box D3 (Foxd3), (10ug)

MG222218 10 µg Ask for price

Foxd3 (Myc-DDK-tagged) - Mouse forkhead box D3 (Foxd3)

MR222218 10 µg Ask for price

FOXD3 (Myc-DDK-tagged)-Human forkhead box D3 (FOXD3)

RC214719 10 µg Ask for price

FoxD3 Mouse mAb

E2220495 100ul
EUR 225
Description: Available in various conjugation types.

FoxD3 Mouse mAb

E2220508 100ul
EUR 225
Description: Available in various conjugation types.

FOXD3 Rabbit pAb

A2926-100ul 100 ul
EUR 369.6

FOXD3 Rabbit pAb

A2926-200ul 200 ul
EUR 550.8

FOXD3 Rabbit pAb

A2926-20ul 20 ul Ask for price

FOXD3 Rabbit pAb

A2926-50ul 50 ul
EUR 267.6

FOXD3 Blocking Peptide

DF3471-BP 1mg
EUR 234

FOXD3 Blocking Peptide

BF0061-BP 1mg
EUR 234

FOXD3 Blocking Peptide

20-abx162435
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  • 1 mg
  • 5 mg

anti- FOXD4 antibody

FNab03192 100µg
EUR 658.5
Description: Antibody raised against FOXD4

Lenti ORF clone of Foxd3 (mGFP-tagged) - Mouse forkhead box D3 (Foxd3)

MR222218L4 10 µg Ask for price

Human FOXD3 shRNA Plasmid

20-abx958926
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  • 150 µg
  • 300 µg

Mouse FOXD3 shRNA Plasmid

20-abx970790
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  • 150 µg
  • 300 µg

Lenti-ORF clone of FOXD3 (mGFP-tagged)-Human forkhead box D3 (FOXD3)

RC214719L2 10 µg Ask for price

Lenti-ORF clone of FOXD3 (mGFP-tagged)-Human forkhead box D3 (FOXD3)

RC214719L4 10 µg Ask for price

AAP32561-100UG - FOXD3 Peptide

AAP32561-100UG 100ug
EUR 99

FOXD3 Recombinant Protein (Mouse)

RP135035 100 ug Ask for price

FOXD3 Recombinant Protein (Human)

RP059061 100 ug Ask for price

anti- FOXD4L6 antibody

FNab03193 100µg
EUR 702
Description: Antibody raised against FOXD4L6

Lenti ORF clone of Foxd3 (Myc-DDK-tagged) - Mouse forkhead box D3 (Foxd3)

MR222218L3 10 µg Ask for price

Lenti-ORF clone of FOXD3 (Myc-DDK-tagged)-Human forkhead box D3 (FOXD3)

RC214719L1 10 µg Ask for price

Lenti-ORF clone of FOXD3 (Myc-DDK-tagged)-Human forkhead box D3 (FOXD3)

RC214719L3 10 µg Ask for price

FOXD3 ORF Vector (Human) (pORF)

ORF019688 1.0 ug DNA Ask for price

Foxd3 ORF Vector (Mouse) (pORF)

ORF045013 1.0 ug DNA
EUR 607.2

FOXD3 DNA-Binding ELISA Kit

abx596491-96tests 96 tests
EUR 867.6

FOXD3 DNA-Binding ELISA Kit

abx596491-100g 100 µg Ask for price

FOXD3 DNA-Binding ELISA Kit

abx596491-200g 200 µg Ask for price

Characterization of PcLEA14, a Group 5 Late Embryogenesis Abundant Protein Gene from Pear ( Pyrus communis)

 Fruit trees need to overcome harsh winter climates to ensure perennially; therefore, they are strongly influenced by environmental stress. In the present study, we focused on the pear homolog PcLEA14 belonging to the unique 5C late embryogenesis abundant (LEA) protein group for which information is limited on fruit trees. PcLEA14 was confirmed to belong to this protein group using phylogenetic tree analysis, and its expression was induced by low-temperature stress.

The seasonal fluctuation in its expression was considered to be related to its role in enduring overwinter temperatures, which is particularly important in perennially. Moreover, the function of PcLEA14 in low-temperature stress tolerance was revealed in transgenic Arabidopsis. Subsequently, the pear homolog of dehydration-responsive element-binding protein/C-repeat binding factor1 (DREB1), which is an important transcription factor in low-temperature stress tolerance and is uncharacterized in pear, was analyzed after bioinformatics analysis revealed the presence of DREB cis-regulatory elements in PcLEA14 and the dormancy-related gene, both of which are also expressed during low temperatures. Among the five PcDREBsPcDREB1A and PcDREB1C exhibited similar expression patterns to PcLEA14 whereas the other PcDREBs were not expressed in winter, suggesting their different physiological roles. Our findings suggest that the low-temperature tolerance mechanism in overwintering trees is associated with group 5C LEA proteins and DREB1.

A role for microRNAs in the epigenetic control of sexually dimorphic gene expression in the human placenta

  •  Aim: The contribution of miRNAs as epigenetic regulators of sexually dimorphic gene expression in the placenta is unknown.
  • Materials & methods: 382 placentas from the extremely low gestational age newborns (ELGAN) cohort were evaluated for expression levels of 37,268 mRNAs and 2,102 miRNAs using genome-wide RNA-sequencing. Differential expression analysis was used to identify differences in the expression based on the sex of the fetus.
  • Results: Sexually dimorphic expression was observed for 128 mRNAs and 59 miRNAs. A set of 25 miRNA master regulators was identified that likely contribute to the sexual dimorphic mRNA expression.
  • Conclusion: These data highlight sex-dependent miRNA and mRNA patterning in the placenta and provide insight into a potential mechanism for observed sex differences in outcomes.

Drug Vulnerabilities and Disease Prognosis Linked to the Stem Cell-Like Gene Expression Program Triggered by the RHO GTPase Activator VAV2 in Hyperplastic Keratinocytes and Head and Neck Cancer

 We have recently shown that VAV2, a guanosine nucleotide exchange factor that catalyzes the stimulation step of RHO GTPases, is involved in a stem cell-like (SCL) regenerative proliferation program that is important for the development and subsequent maintenance of the tumorigenesis of both cutaneous (cSCC) and head and neck squamous cell carcinomas (hnSCC). In line with this, we have observed that the levels of the VAV2 mRNA and VAV2-regulated gene signatures are associated with poor prognosis in the case of human papillomavirus-negative hnSCC patients.

These results suggest that the SCL program elicited by VAV2 in those cells can harbor therapeutically actionable downstream targets. We have addressed this issue using a combination of both in silico and wet-lab approaches. Here, we show that the VAV2-regulated SCL program does harbor a number of cell cycle- and signaling-related kinases that are essential for the viability of undifferentiated keratinocytes and hnSCC patient-derived cells endowed with high levels of VAV2 activity. Our results also show that the VAV2-regulated SCL gene signature is associated with poor hnSCC patient prognosis. Collectively, these data underscore the critical role of this VAV2-regulated SCL program for the viability of both preneoplastic and fully transformed keratinocytes

Antibody Coating Buffer, 5X

645 500 mL
EUR 165

Antibody Coating Buffer, 5X

646 1 L
EUR 318

5x ELISA COATING BUFFER Reagent

GWB-Q00204 100 ml Ask for price

5x ELISA COATING BUFFER Reagent

GWB-Q00205 500 ml Ask for price

5x ELISA COATING BUFFER Reagent

GWB-Q00206 1000 ml Ask for price

Coating Buffer

abx098970-1vial 1 vial
EUR 184.8

Coating Buffer

RM01756 20mL
EUR 280

Coating Buffer

DS0236-100ML 1 unit
EUR 2.8
Description: Coating Buffer

Coating Buffer

DS0236-500ML 1 unit
EUR 12.71
Description: Coating Buffer

Coating Buffer

abx098970-100l 100 µl
EUR 93.75

Coating Buffer

abx098970-1ml 1 ml Ask for price

Coating Buffer

abx098970-200l 200 µl Ask for price

Coating Buffer, 20X, 100ML

X108-100ML 100ML
EUR 120

Coating Buffer, 20X, 10ML

X108-10ML 10ML
EUR 37

ELISA Coating Buffer 10X

DPCP-100mL 100 mL
EUR 43.32

ELISA Coating Buffer 10X

DPCP-1Liter 1 Liter
EUR 164.92

Binding/Coating Buffer (10X)

85R-124 250 ml
EUR 200
Description: ELISA buffer for optimal coating and binding of antibodies and antigens

Plate Coating Buffer-CB1

KF17336 500 ml
EUR 292.8

ELISA Plate Coating Buffer-1×-

E-ELIR-001-24Tests 24 Tests Ask for price

ELISA Plate Coating Buffer-1×-

E-ELIR-001-48Tests 48 Tests
EUR 50

ELISA Plate Coating Buffer-1×-

E-ELIR-001-96Tests 96 Tests
EUR 10

ELISA Plate Coating Buffer-1×-

E-ELIR-001-96Tests10 96 Tests *10
EUR 100

ELISA Plate Coating Buffer-1×-

E-ELIR-001-96Tests5 96 Tests *5
EUR 50

ELISA Plate Coating Buffer-5×-

E-ELIR-002-24Tests 24 Tests Ask for price

ELISA Plate Coating Buffer-5×-

E-ELIR-002-48Tests 48 Tests
EUR 120

ELISA Plate Coating Buffer-5×-

E-ELIR-002-96Tests 96 Tests
EUR 40

ELISA Plate Coating Buffer-5×-

E-ELIR-002-96Tests10 96 Tests *10
EUR 400

ELISA Plate Coating Buffer-5×-

E-ELIR-002-96Tests5 96 Tests *5
EUR 200

Blocking Buffer and Coating Stabilizer

abx090811-1000ml 1000 ml
EUR 627.6

Blocking Buffer and Coating Stabilizer

abx090811-100l 100 µl
EUR 725

Blocking Buffer and Coating Stabilizer

abx090811-1ml 1 ml Ask for price

Blocking Buffer and Coating Stabilizer

abx090811-200l 200 µl Ask for price

Carbonate-bicarbonate Coating buffer pH 9.6, 100 ml

09-8922-100 100 ml
EUR 129.6

Carbonate-bicarbonate Coating buffer pH 9.6, 100 ml

09-8922-24 100 ml
EUR 98.4

Coating Buffer for ELISA, with preservative (500 ml)

643005 500 ml
EUR 61
Description: Coating Buffer for ELISA, with preservative (500 ml)

OOSA09545-1L - ELISA COATING BUFFER Accessory Reagent

OOSA09545-1L 1000ml
EUR 549

OOSA09543-100ML - ELISA COATING BUFFER Accessory Reagent

OOSA09543-100ML 100ml
EUR 129

OOSA09544-500ML - ELISA COATING BUFFER Accessory Reagent

OOSA09544-500ML 500ml
EUR 359

Carbonate-bicarbonate Coating buffer with Azide pH 9.6, 100 ml

09-8932-50 100 ml
EUR 153.6

Carbonate-bicarbonate Coating buffer with Azide pH 9.6, 100 ml

09-8932-8 100 ml
EUR 98.4

Carcinoembryonic Antigen Coating Antibody, Antibody

GWB-2E6A0C 1 mg Ask for price

Recombinant HIV type 1 gp41 Antigen, Coating

DAG-WT1177 1 mg
EUR 420
Description: Recombinant

Anti-GPC1 McAb (Coating)

E61C03401 100ug
EUR 225
Description: Available in various conjugation types.

coating ab of 044

044-1 100µg
EUR 198

coating ab of 041

041-1 100µg
EUR 165

coating ab of 043

043-1 100µg
EUR 165

Coating Stabilizer

CSB125 125 ml
EUR 24.43

Coating Stabilizer

CSB500 500 ml
EUR 47.58

Coating Stabilizer

CSB999 1000 ml
EUR 86.15

Anti-CEA McAb (coating)

E61C00205a 1mg
EUR 287.5
Description: Available in various conjugation types.

Anti-CEA McAb (Coating)

E61C00207 1mg
EUR 287.5
Description: Available in various conjugation types.

Anti-AFP McAb (Coating)

E61C00305 1mg
EUR 1125
Description: Available in various conjugation types.

Anti-TPA McAb (coating)

E61C01301 1mg
EUR 1125
Description: Available in various conjugation types.

Anti-CK8 McAb (coating)

E61C01701 1mg
EUR 1125
Description: Available in various conjugation types.

Anti-PGI McAb (coating)

E61C01801 100ug
EUR 225
Description: Available in various conjugation types.

Anti-HE4 McAb (Coating)

E61C02601 100ug
EUR 225
Description: Available in various conjugation types.

Anti-HE4 McAb (Coating)

E61C02601a 1mg
EUR 1125
Description: Available in various conjugation types.

Anti-HBS McAb (coating)

E61H00202 1mg
EUR 115
Description: Available in various conjugation types.

Anti-HBe McAb (coating)

E61H00401 1mg
EUR 143.75
Description: Available in various conjugation types.

Anti-HBc McAb (coating)

E61H00601 1mg
EUR 143.75
Description: Available in various conjugation types.

Anti-CRP McAb (coating)

E63C00601 100ug
EUR 225
Description: Available in various conjugation types.

Anti-CRP McAb (coating)

E63C00604 100ug
EUR 225
Description: Available in various conjugation types.

Anti-PCT McAb (coating)

E63C00901 100ug
EUR 225
Description: Available in various conjugation types.

Anti-PCT McAb (coating)

E63C00903 100ug
EUR 225
Description: Available in various conjugation types.

Anti-SCCA McAb (coating)

E61C01401 100ug
EUR 225
Description: Available in various conjugation types.

Anti-SCCA McAb (coating)

E61C01401a 1mg
EUR 1000
Description: Available in various conjugation types.

Anti-CK18 McAb (coating)

E61C01801a 1mg
EUR 1125
Description: Available in various conjugation types.

Anti-PGII McAb (coating)

E61C01901 100ug
EUR 225
Description: Available in various conjugation types.

Anti-CK20 McAb (coating)

E61C02001 1mg
EUR 1125
Description: Available in various conjugation types.

Anti-MCM5 McAb (Coating)

E61C03301 100ug
EUR 225
Description: Available in various conjugation types.

Anti-NGAL McAb (Coating)

E61K00801 100ug
EUR 225
Description: Available in various conjugation types.

Anti-cTnI McAb (coating)

E63C00401a 100ug
EUR 225
Description: Available in various conjugation types.

Anti-FABP McAb (coating)

E63C00801 100ug
EUR 225
Description: Available in various conjugation types.

Anti-ABCA7 McAb (coating)

E61B00801 100ug
EUR 225
Description: Available in various conjugation types.

Anti-CA125 McAb (coating)

E61C01201 100ug
EUR 225
Description: Available in various conjugation types.

Anti-CA125 McAb (coating)

E61C01201a 1mg
EUR 1000
Description: Available in various conjugation types.

Anti-SUPAR McAb (Coating)

E61K00701 100ug
EUR 225
Description: Available in various conjugation types.

Peptide Coating Kit

GWB-3F7464 Reagent Ask for price

Anti-S100BB McAb (coating)

E61B00201 100ug
EUR 225
Description: Available in various conjugation types.

Anti-LpPLA2 McAb (coating)

E63C01001 100ug
EUR 225
Description: Available in various conjugation types.

Anti-S100A1B McAb (coating)

E61B00101 20ug
EUR 225
Description: Available in various conjugation types.

Anti-Insulin McAb (coating)

E63I00501 1mg
EUR 575
Description: Available in various conjugation types.

iPSC Coating Solution

cAP-50 100ml
EUR 178.2

Anti-Ferritin McAb (coating)

E61C01501 100ug
EUR 225
Description: Available in various conjugation types.

Anti-Ferritin McAb (coating)

E61C01501a 1mg
EUR 575
Description: Available in various conjugation types.

Quick Coating Solution

cAP-01 240ml
EUR 133.65

Anti-Myoglobin McAb (coating)

E63C00301 100ug
EUR 225
Description: Available in various conjugation types.

Anti-CK-Mb McAb (coating)

E63C00101a 100ug
EUR 225
Description: Available in various conjugation types.

Anti-CK-Mb McAb (coating)

E63C00101b 100ug
EUR 225
Description: Available in various conjugation types.

Matrigel Coating Solution

cAP-58 100ml
EUR 178.2

Anti-CA15-3 McAb (coating)

E61C00801a 1mg
EUR 1250
Description: Available in various conjugation types.

Anti-CA15-3 McAb (coating)

E61C00802 100ug
EUR 225
Description: Available in various conjugation types.

Anti-CA24-2 McAb (coating)

E61C01001 100ug
EUR 225
Description: Available in various conjugation types.

Anti-CA24-2 McAb (coating)

E61C01001a 1mg
EUR 1250
Description: Available in various conjugation types.

Anti-CA72-4 McAb (coating)

E61C01101 100ug
EUR 225
Description: Available in various conjugation types.

Anti-CA72-4 McAb (coating)

E61C01101a 1mg
EUR 1250
Description: Available in various conjugation types.

Anti-Pro-GRP McAb (Coating)

E61C03201 100ug
EUR 225
Description: Available in various conjugation types.

Anti-Pro-BNP McAb (coating)

E63C00501a 100ug
EUR 225
Description: Available in various conjugation types.

Anti-NT-Pro-BNP (Coating)

E63C00503 100ug
EUR 225
Description: Available in various conjugation types.

Anti-D-dimer McAb (coating)

E63C00701 100ug
EUR 225
Description: Available in various conjugation types.

Antigen Retrieval buffer(50X)Citrate buffer of pH6.0

E11-120002 100ml
EUR 225

Antigen Retrieval buffer(50X)Citrate buffer of pH6.0

E44H14718 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Anti-alfa-HCG McAb (coating)

E61C00101 100ug
EUR 225
Description: Available in various conjugation types.

Anti-C-Peptide McAb (coating)

E63I00601 1mg
EUR 750
Description: Available in various conjugation types.

Anti-CA50 McAb (coating&labeling)

E61C01602 1mg
EUR 1125
Description: Available in various conjugation types.

Gelatin Coating Solution (0.1%)

TM063 100 ml
EUR 100

OOMA00015-125ML - Coating Stabilizer & Block Buf

OOMA00015-125ML 1000ML
EUR 499

Citrate Buffer with Tween pH 6.0 (Antigen Retrieval Buffer)

RRSP5115-E 1L
EUR 10.83

Citrate Buffer with Tween pH 6.0 (Antigen Retrieval Buffer)

RRSP5115-F 2.5L
EUR 18.17

FNC Coating Mix®, 100 ml

0407 100 mL
EUR 157.7

Anti-Cyfra21-1 (CK19) McAb (coating)

E61C00701a 1mg
EUR 1125
Description: Available in various conjugation types.

Anti-Cyfra21-1 (CK19) McAb (coating)

E61C00704 100ug
EUR 225
Description: Available in various conjugation types.

Anti-Cyfra21-1 (CK19) McAb (coating)

E61C00706 100ug
EUR 225
Description: Available in various conjugation types.

Anti-free-Beta-HCG McAb (coating)

E61C00103 100ug
EUR 225
Description: Available in various conjugation types.

Anti-CA19-9 McAb (coating&labeling)

E61C00901 100ug
EUR 225
Description: Available in various conjugation types.

Anti-CA19-9 McAb (coating&labeling)

E61C00901a 1mg
EUR 718.75
Description: Available in various conjugation types.

Anti-CA19-9 McAb (coating&labeling)

E61C00902 100ug
EUR 225
Description: Available in various conjugation types.

Anti-CA19-9 McAb (coating&labeling)

E61C00902a 1mg
EUR 718.75
Description: Available in various conjugation types.

EDTA Buffer pH 8.0 Antigen Retrieval Buffer (10 x Concentrate)

RRSP5116-B 100ml
EUR 9.06

TBE Buffer, 5X

41006-1 EA
EUR 70

5X TBE Buffer

T8051-100 2X500ml
EUR 98.4

5X TBE Buffer

T8051-200 4X500ml
EUR 128.4

Antibody/Antigen Purification Buffer Kit

21310001-1 1 Kit
EUR 76.66

Anti-Protein-N(SARS-CoV-2)(Coating)

E28F03081-C Coating-antibody
EUR 416.5
Description: Coating antibody

Anti-Protein-S(SARS-CoV-2)(Coating)

E28F03082-C Humanized-Fc-antibody,-EC50=0.86ug/ml
EUR 416.5
Description: Humanized Fc antibody, EC50=0.86ug/ml

5X RIPA Buffer

AKR-191 20mL
EUR 80

5x Stop Buffer

TG4037 1ml
EUR 187.2

Kinase Buffer 5X

41120000-1 100 mL
EUR 25.1

Kinase Buffer 5X

41120000-2 250 mL
EUR 51.8

Kinase Buffer 5X

41120000-3 500 mL
EUR 85.98

5X Laemmli Buffer

ML121-10ML 1 unit
EUR 10.17
Description: 5X Laemmli Buffer

5X Laemmli Buffer

ML121-5ML 1 unit
EUR 5.68
Description: 5X Laemmli Buffer

Fibronectin Coating Solution (1 mg/mL)

TM059 1.0 mg
EUR 215

Vitronectin Coating Solution (0.5 mg/ml)

TM060 0.2 ml
EUR 580

Poly-L-Lysine Coating Solution (0.1%)

TM061 25 ml
EUR 70

Phosphatase Buffer 5X

41620003-1 100 mL
EUR 27.46

Phosphatase Buffer 5X

41620003-2 250 mL
EUR 45.77

Phosphatase Buffer 5X

41620003-3 500 mL
EUR 86.94

Phosphatase Buffer 5X

41620003-4 1 L
EUR 164.71

Phosphatase Buffer 5X

41620003-5 4 L
EUR 594.8

Collagen (Type I) Coating Solution (Bovine)

cAP-30 100ml
EUR 118.8

Citrate Buffer with Tween pH 6.0 (10 x Concentrate) Antigen Retrieval Buffer

RRSP5118-B 100ml
EUR 10.19

FNC Coating Mix® - Human Proteins, 100ml

0407H 50 ml
EUR 191.9

Recombinant HTLV gp21 Protein (Coating) [2B3A]

VAng-Lsx0306-inquire inquire Ask for price
Description: HTLV gp21 Antigen [2B3A], Recombinant antigen.

Coating Antibody or Protein stabilizer solution (10X)

PRTS-100 100 ml
EUR 343.2

Kinase Buffer II 5X

41120001-1 100 mL
EUR 72.75

Kinase Buffer II 5X

41120001-2 250 mL
EUR 135

Kinase Buffer II 5X

41120001-3 500 mL
EUR 210

Kinase Buffer IV 5X

41120003-1 100 mL
EUR 72.75

Kinase Buffer IV 5X

41120003-2 250 mL
EUR 135

Kinase Buffer IV 5X

41120003-3 500 mL
EUR 210

Kinase Buffer V 5X

41120004-1 100 mL
EUR 72.75

Kinase Buffer V 5X

41120004-2 250 mL
EUR 135

Kinase Buffer V 5X

41120004-3 500 mL
EUR 210

5X PTP Assay Buffer

79716 20 ml
EUR 195
Description: Extra assay buffer for use with the PTP Colorimetric assay kit (BPS Bioscience, Cat. #30019), or related PTP assay kits, for the study of protein tyrosine phosphatase activity.

Buffer B 5X, Sterile

40120742-1 100 mL
EUR 24.71

Buffer B 5X, Sterile

40120742-2 500 mL
EUR 35.69

Buffer B 5X, Sterile

40120742-3 1 L
EUR 67.72

TE Buffer 5X, Sterile

40121086-1 100 mL
EUR 15.55

TE Buffer 5X, Sterile

40121086-2 250 mL
EUR 26.54

TE Buffer 5X, Sterile

40121086-3 500 mL
EUR 44.84

Kinase Buffer III 5X

41120002-1 100 mL
EUR 72.75

Kinase Buffer III 5X

41120002-2 250 mL
EUR 135

Kinase Buffer III 5X

41120002-3 500 mL
EUR 210

5X CD73 Assay Buffer

74000 10 ml
EUR 195
Description: The 5X CD73 Assay Buffer is optimized for assaying CD73. This buffer is designed for BPS Bioscience's colorimetric assays (cat# 72055 and cat# 72058).

5x HSP90 Assay Buffer

50311 20 ml
EUR 180
Description: Concentrated aqueous buffer optimized for use with the following BPS Bioscience HSP90 assay kits:
• HSP90α Assay Kit (96 well) #50293 96 reactions
• HSP90α Assay Kit (384 well) #50298 384 reactions
• HSP90β Assay Kit (96 well) #50294 96 reactions
• HSP90β Assay Kit (384 well) #50299 384 reactions
Note: This buffer is not designed for use with the HSP90β (C-Terminal) Inhibitor Screening Assay Kit, Cat. # 50314.

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